[1]聂欢,李桓,肖文秀,等.重庆地区艾滋病患者合并肺结核感染的流行状况及相关危险因素分析[J].第三军医大学学报,2018,40(21):2006-2010.
 NIE Huan,LI Huan,XIAO Wenxiu,et al.Prevalence and risk factors of HIV/TB co-infection among HIV infected patients in Chongqing[J].J Third Mil Med Univ,2018,40(21):2006-2010.
点击复制

重庆地区艾滋病患者合并肺结核感染的流行状况及相关危险因素分析(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第21期
页码:
2006-2010
栏目:
公共卫生与预防医学
出版日期:
2018-11-15

文章信息/Info

Title:
Prevalence and risk factors of HIV/TB co-infection among HIV infected patients in Chongqing
作者:
聂欢李桓肖文秀董剑唐君文黄成瑜

重庆市公共卫生医疗救治中心:预防保健科,感染门诊,信息科
Author(s):
NIE Huan LI Huan XIAO Wenxiu DONG Jian TANG Junwen HUANG Chengyu

Department of Preventive Health Care, Clinic of Infective Diseases, Department of Information, Chongqing Public Health Medical Center, Chongqing, 40038, China

关键词:
艾滋病肺结核危险因素重庆市
Keywords:
acquired immunodeficiency syndrome tuberculosis pulmonary risk factors Chongqing  
分类号:
R195.4; R512.91; R52
文献标志码:
A
摘要:

目的分析重庆市接受抗病毒治疗的艾滋病患者合并肺结核的感染率以及相关的危险因素。方法应用艾滋病综合防治系统——抗病毒治疗管理系统,收集重庆市2004-2015年各艾滋病治疗定点医院中接受抗病毒治疗患者的基本信息以及肺结核感染信息。分析艾滋病患者人群中合并肺结核的感染率,利用多因素Logistic回归模型分析影响艾滋病患者发生肺结核合并感染的影响因素。结果19 512例艾滋病患者中,1 109例患有肺结核,艾滋病患者中合并肺结核的感染率为5.68%。采用多因素Logistic回归模型进行分析发现:年龄在30~45岁的艾滋病患者更容易合并肺结核感染(校正后OR=1.238,95%CI:1.035~1.481);男性艾滋病患者更容易合并肺结核感染(校正后OR=1.645,95%CI:1.393~1.942);WHO临床分期为Ⅲ期、Ⅳ期的艾滋病患者比Ⅰ期患者更容易合并肺结核感染(Ⅲ期患者校正后OR=2.734,95%CI:2.235~3.345;Ⅳ期患者校正后OR=3.144,95%CI:2.630~3.759);基线CD4≤200的艾滋病患者更容易合并肺结核感染(校正后OR=5.244,95%CI: 4.444~6.188)。结论30~45岁人群、男性、Ⅲ期和Ⅳ期艾滋病患者以及基线CD4值≤200的患者更容易发生肺结核合并感染。

Abstract:

ObjectiveTo analyze the prevalence and risk factors of HIV/tuberculosis (TB) coinfection among HIV infected patients in Chongqing. MethodsThe study was based on the AIDS Integrated Control System-anti-virus Treatment Management Database. The demographic characteristics and TB infection information of HIV infected patients were collected from 2004 to 2015 in Chongqing. The prevalence of TB infection among AIDS patients was analyzed. Multivariate logistic regression analysis was used to determine the influencing factors of TB infection in these patients. ResultsAmong the 19 513 AIDS subjects, 1 109 suffered from TB, with a prevalence of 5.68%. Multivariate logistic regression analysis revealed that the patients aged from 30 to 45 years were prone to TB (adjusted OR=1.238, 95%CI: 1.035~1.481); males were more prone to catch TB than females (adjusted OR=1.645, 95%CI : 1.393~1.942); the subjects at WHO clinical stages Ⅲ and Ⅳ were more prone to the disease than those at stage Ⅰ (stage Ⅲ: adjusted OR=2.734, 95%CI: 2.235~3.345; stage Ⅳ: adjusted OR=3.144, 95%CI: 2.630~3.759); those with baseline CD4≤200 were more prone (adjusted OR=5.244, 95%CI: 4.444~6.188). ConclusionAIDS patients, male, 30~45 years old, at WHO stages Ⅲ and Ⅳ, and with baseline CD4 values ≤200 are more prone to TB co-infection.

参考文献/References:

[1]TIBERI S, CARVALHO A C, SULIS G, et al. The cursed duet today: tuberculosis and HIVcoinfection[J]. Presse Med, 2017, 46(2 Pt 2): e23-e39. DOI:10.1016/j.lpm.2017.01.017.
[2]GAO J, ZHENG P, FU H. Prevalence of TB/HIV coinfection in countries except China: a systematic review and metaanalysis[J]. PLoS ONE, 2013, 8(5): e64915. DOI:10.1371/journal.pone.0064915.
[3]张湘玲. 2005-2012 年凭祥市结核病和艾滋病(TB/HIV)双重感染人群资料分析[J]. 医学动物防制,2014,30(6): 624-626.
ZHANG X L. Double infection population data analysis of Tuberculosis and HIV/AIDS (TB/HIV) of Pingxiang city during 2005-2012[J]. J Med Pest Control, 2014, 30(6): 624-626.
[4]CHANDAKAPATA P, KAPATA N, KLINKENBERG E, et al. The prevalence of HIV among adults with pulmonary TB at a population level in Zambia[J]. BMC Infect Dis, 2017, 17(1): 236. DOI: 10.1186/s1287901723455.
[5]聂欢,肖文秀,唐德谊,等. 分析重庆市HIV/AIDS患者合并HBV、HCV感染状况[J]. 第三军医大学学报, 2017,39(21): 2140-2144.DOI:10.16016/j.10005404.201705085.
NIE H,XIAO W X,TANG D Y,et al.Retrospective analysis of HBV and HCV infection in HIV/AIDS patients in Chongqing[J].J Third Mil Med Univ,2017,39(21):2140-2144.DOI:10.16016/j.10005404.201705085.
[6]中华医学会结核病分会. 肺结核诊断和治疗指南[J]. 中华结核和呼吸杂志, 2001, 24(2): 70-74.
Chinese Society for Tuberculosis, Chinese Medical Association. Guidelines for the diagnosis and treatment of tuberculosis[J]. Chin J Tuberc Respir Dis, 2001, 24(2): 70-74.
[7]霍飞,方彦. 2005-2014年艾滋病合并结核病国际研究状况文献计量学分析[J]. 中国艾滋病性病, 2016, 22(7): 536-538.DOI:10.13419/j.cnki.aids.2016.07.14.
HUO F,FANG Y. Bibliometric analysis of domestic and overseas literature on coinfected with TB and HIV[J]. Chin J AIDS STD,2016, 22(7): 536-538.DOI:10.13419/j.cnki.aids.2016.07.14.
[8]孙月,郜桂菊,李兴旺. 艾滋病合并结核病研究进展[J]. 中国艾滋病性病, 2013,8: 619-621.DOI:10.13419/j.cnki.aids.2013.08.027.
SUN Y, GAO G J, LI X W. Novel developments in AIDS/TB coinfection[J]. Chin J AIDS STD, 2013(08): 619-621.DOI:10.13419/j.cnki.aids.2013.08.027.
[9]NANTA S, KANTIPONG P, PATHIPVANICH P, et al. Screening scheme development for active TB prediction among HIVinfected patients[J]. Southeast Asian J Trop Med Public Health, 2011, 42(4): 867-875.
[10]JALAL T M T, ABDULLAH S, WAHAB F A, et al. Prevalence and factors associated with tuberculosis treatment success among TB/HIV coinfection in Northeast Malaysia[J]. Malays J Med Sci, 2017, 24(6): 75-82. DOI:10.21315/mjms2017.24.6.9.
[11]崔哲哲,冯启明,林玫,等. 2010~2013年广西TB/HIV双重感染监测数据分析与评价[J]. 广西医学, 2015,37(3): 364-367.
CUI Z Z,FENG Q M,LIN M, et al. Analysis and evaluation on TB/HIV coinfection monitoring result in Guangxi from 2010 to 2013[J]. Guangxi Med J, 2015, 37(3): 364-367.
[12]张淑兰,单志力,毛玲琼,等. 2011-2013年浙江省温州市结核菌/艾滋病病毒双重感染筛查与治疗资料分析[J]. 疾病监测, 2015,30(1): 42-45.
ZHANG S L,SHAN Z L ,MAO L Q, et al. Screening and treatment of Mycobacterium tuberculosis/HIV coinfection in Wenzhou,Zhejiang,2011-2013[J]. Dis Surveillance, 2015,30(1): 42-45.
[13]NGOWI B J, MFINANGA S G, BRUUN J N, et al. Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania[J]. BMC Public Health, 2008, 8: 341. DOI:10.1186/147124588341.
[14]MITKU A A, DESSIE Z G, MULUNEH E K, et al. Prevalence and associated factors of TB/HIV coinfection among HIV infected patients in Amhara region, Ethiopia[J]. Afr Health Sci, 2016, 16(2): 588-595. DOI:10.4314/ahs.v16i2.29.
[15]AKANBI M O, ACHENBACH C J, FEINGLASS J, et al. Tuberculosis after one year of combination antiretroviral therapy in Nigeria: a retrospective cohort study[J]. AIDS Res Hum Retroviruses, 2013, 29(6): 931-937. DOI:10.1089/AID.2012.0231.
[16]SCHABLON A, BECKMANN G, HARLING M, et al. Prevalence of latent tuberculosis infection among health care workers in a hospital for pulmonary diseases[J]. J Occup Med Toxicol, 2009, 4: 1. DOI:10.1186/1745667341.
[17]LIENHARDT C, FIELDING K, SILLAH J S, et al. Investigation of the risk factors for tuberculosis: a casecontrol study in three countries in West Africa[J]. Int J Epidemiol, 2005, 34(4): 914-923. DOI:10.1093/ije/dyi100.
[18]TAHA M, DERIBEW A, TESSEMA F, et al. Risk factors of active tuberculosis in people living with HIV/AIDS in Southwest Ethiopia: a case control study[J]. Ethiop J Health Sci, 2011, 21(2): 131-139. DOI:10.4314/ejhs.v21i2.69053.

相似文献/References:

[1]鄢仁晴,罗军敏,孙万邦,等.肺结核患者外周血树突状细胞亚群的变化[J].第三军医大学学报,2007,29(13):1298.
 YAN Ren-qing,LUO Jun-min,SUN Wan-bang,et al.Changes of peripheral blood dendritic cell subgroup in pulmonary tuberculosis patients[J].J Third Mil Med Univ,2007,29(21):1298.
[2]胡良安,李岱容,罗永艾,等.肺结核患者外周血中CD4+CD25+FoxP3+调节T细胞增多并抑制抗结核免疫[J].第三军医大学学报,2011,33(20):2124.
 Hu Liangan,Li Dairong,Luo Yongai,et al.Peripheral blood CD4+CD25+FoxP3+ regulatory T cells in active pulmonary tuberculosis patients[J].J Third Mil Med Univ,2011,33(21):2124.
[3]付留杰,熊鸿燕,刘元东,等.某部队肺结核患病现况及发病影响因素的流行病学研究[J].第三军医大学学报,2005,27(13):1400.
[4]刘琦,刘新宇,张仁卿,等.汉、藏族肺结核患者血清差异蛋白质的质谱分析[J].第三军医大学学报,2010,32(18):1986.
 Liu Qi,Liu Xinyu,Zhang Renqing,et al.Mass spectrometry for serum differential proteins from Han and Tibetan patients with pulmonary tuberculosis[J].J Third Mil Med Univ,2010,32(21):1986.
[5]李素芝,蒋亚建,谢本维,等.中国藏族人群HLA-DRB1、-DQA1、-DQB1等位基因多态性与肺结核易感性的关联性研究[J].第三军医大学学报,2011,33(12):1254.
 Li Suzhi,Jiang Yajian,Xie Benwei,et al.Correlation between polymorphisms of DRB1, -DQA1, and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China[J].J Third Mil Med Univ,2011,33(21):1254.
[6]高晓凤,贾显奉,许平,等.西部2个贫困县肺结核患者发现延误情况及其影响因素分析[J].第三军医大学学报,2012,34(14):1471.
[7]杨先涛,张祯祯,詹学,等.肺结核患儿外周血单个核细胞中microRNA表达的初步研究[J].第三军医大学学报,2013,35(19):2051.
 Yang Xiantao,Zhang Zhenzhen,Zhan Xue,et al.microRNA expression in peripheral blood mononuclear cells from pulmonary tuberculosis children[J].J Third Mil Med Univ,2013,35(21):2051.
[8]孙芬芬,曹晖,曹国强.结节性脂膜炎误诊肺结核1例[J].第三军医大学学报,2013,35(21):2300.
[9]李敏,俞炽阳,李玉艳,等.体外受精-胚胎移植术后重度卵巢过度刺激综合征、双胎、胎儿畸形引产1例[J].第三军医大学学报,2013,35(24 ):2609.
[10]罗效梅,熊玉霞,曹均,等.全血γ干扰素诱导蛋白-10释放试验对活动性肺结核的诊断价值[J].第三军医大学学报,2013,35(19):2092.
 Luo Xiaomei,Xiong Yuxia,Cao Jun,et al.Diagnostic value of whole blood gamma interferon-inducible protein 10 release assay in active pulmonary tuberculosis[J].J Third Mil Med Univ,2013,35(21):2092.

更新日期/Last Update: 2018-11-19