[1]蒲美君,李自杨,黄小勇.早期家族性渗出性玻璃体视网膜病变的黄斑特征研究[J].第三军医大学学报,2018,40(10):923-927.
 PU Meijun,LI Ziyang,HUANG Xiaoyong.Evaluation of macular changes in early-stage familial exudative vitreoretinopathy: a cross-sectional, casecontrol study[J].J Third Mil Med Univ,2018,40(10):923-927.
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早期家族性渗出性玻璃体视网膜病变的黄斑特征研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第10期
页码:
923-927
栏目:
临床医学
出版日期:
2018-05-30

文章信息/Info

Title:
Evaluation of macular changes in early-stage familial exudative vitreoretinopathy: a cross-sectional, casecontrol study
作者:
蒲美君李自杨黄小勇
陆军军医大学(第三军医大学)第一附属医院眼科
Author(s):
PU Meijun LI Ziyang HUANG Xiaoyong

Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China

关键词:
家族性渗出性玻璃体视网膜病变频域光学相干断层扫描黄斑中心凹厚度黄斑发育最佳矫正视力
Keywords:
familial exudative vitreoretinopathy spectral-domain optical coherencetomography central
分类号:
R195.4;R774.1;R774.5
文献标志码:
A
摘要:

目的    观察早期家族性渗出性玻璃体视网膜病变(familial exudative vitreoretinopathy, FEVR)患者的黄斑特征,并探讨其有无先天性黄斑发育异常。方法    采用横断面研究,共纳入2014年9月至2017年10月在陆军军医大学第一附属医院就诊的FEVR患者31例37眼,对照组30例30眼。应用SD-OCT获取黄斑部图像,测量最佳矫正视力及黄斑中心凹厚度,采用SPSS23.0统计软件作数据分析。结果    早期FEVR患者黄斑中心凹厚度与对照组相比,差异无统计学意义。早期FEVR患者黄斑结构异常有11眼(29.7%),均为继发性黄斑结构异常,其中椭圆体带连续性中断较为常见,黄斑结构正常26眼(70.3%),黄斑结构异常组视力低于黄斑结构正常组,差异有统计学意义(P=0.001),黄斑结构正常组视力与对照组相比,差异无统计学意义。结论    FEVR患者无先天性黄斑发育异常,多数患者黄斑结构正常,一旦发生继发性黄斑结构异常,可显著影响视力。OCT是监测FEVR病变进展的重要手段。

Abstract:

Objective    To observe the macular changes and investigate the presence of congenital macular dysplasia in patients with familial exudative vitreoretinopathy (FEVR). Methods    This cross-sectional, case-control study was conducted among 31 patients with early-stage FEVR (37 eyes) treated in the First Affiliated Hospital of the Army Medical University between September, 2014 to October, 2017, with 30 healthy subjects (30 eyes) as the control group. All the subjects underwent examinations of the best corrected visual acuity (BCVA), spectral-domain optical coherencetomography (SD-OCT) and fluorescence fundus angiography (FFA). Results    No significant difference was found in the central foveal thickness between FEVR group and control group. In FEVR group, 11 eyes (29.7%) in 8 cases showed macular abnormalities, which were all secondary abnormalities featuring a disruption of the ellipsoid zone as the most common finding on SDOCT; 26 eyes (70.3%) in 25 cases had normal macula. The eyes with macular abnormalities had a significantly lower BCVA than those with normal macular findings (P=0.001). No significant difference was found in the BCVA between the eyes in normal macular group and control group. Conclusion    Patients with FEVR do not have congenital developmental abnormalities in the macula, and most of the patients with early-stage FEVR have normal macula. However, secondary macular abnormalities can lead to severe visual impairment, and OCT can serve as an important means to monitor the progression of FEVR.

参考文献/References:

[1]CRISWICK V G, SCHEPENS C L. Familial exudative vitreoretinopathy[J]. Am J Ophthalmol, 1969, 68(4): 578-594.
[2]PENDERGAST S D, TRESE M T. Familial exudative vitreoretinopathy. Results of surgical management[J]. Ophthalmology, 1998, 105(6): 1015-1023. DOI: 10.1016/S01616420(98)96002X.
[3]MIYAKUBO H, HASHIMOTO K,MIYAKUBO S. Retinal vascular pattern in familial exudative vitreoretinopathy[J]. Ophthalmology, 1984, 91(12): 1524-1530.
[4]CHEN S N, HUANG J F,LIN C J. Clinical characteristics and surgical management of familial exudative vitreoretinopathyassociated rhegmatogenous retinal detachment[J]. Retina, 2012, 32(2): 220-225.DOI:10.1097/IAE.0b013e31821c3ec5.
[5]YUAN M, YANG Y, YAN H, et al.Increased posterior retinal vessels in mild asymptomatic familial exudative vitreoretinapathy eyes[J].Retina, 2016, 36(6): 1209-1215.DOI: 10.1097/IAE.0000000000000830.
[6]YONEKAWA Y, THOMAS B J, DRENSER K A,et al.Familial exudative vitreoretinopathy: spectraldomain optical coherence tomography ofthevitreoretinal interface, retina, and choroid[J].Ophthalmology, 2015, 122(11): 2270-2277. DOI: 10.1016/j.ophtha.2015.07.024.
[7]WELEBER R G,PENNESI M E, WILSON D J, et al. Results at 2 years after gene therapy for RPE65deficient leber congenital amaurosis and severe early-childhood-onset retinal dystrophy[J]. Ophthalmology, 2016, 123(7): 1606-1620. DOI: 10.1016/j.ophtha.2016.03.003.
[8]CHACON-CAMACHO-F,ZENTENO J C.Gene therapy for vision restoration in patients with Leber congenital amaurosis (LCA) due to RPE65 gene mutations: beginning the phase Ⅳ trial[J]. Gac Med Mex, 2017, 153(2): 276-278.
[9]BAINBRIDGE J W, MEHAT M S, SUNDARAM V, et al. Longterm effect of gene therapy on Leber’s congenital amaurosis[J]. N Engl J Med, 2015, 372(20): 1887-1897. DOI: 10.1056/NEJMoa1414221.
[10]TERAUCHI G, SHINODA K, MATSUMOTO C S, et al. Recovery of photoreceptor inner and outer segment layer thickness after reattachment of rhegmatogenous retinal detachment[J]. Br J Ophthalmol, 2015, 99(10): 1323-1327. DOI: 10.1136/bjophthalmol2014306252.
[11]GROSSNIKLAUS H E,GREEN W R. Pathologic findings in pathologic myopia[J]. Retina, 1992, 12(2): 127-133.
[12]SPAIDE R F, KLANCNIK J M JR,COONEY M J.Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography[J]. JAMA Ophthalmol, 2015, 133(1): 45-50. DOI: 10.1001/jamaophthalmol.2014.3616.
[13]SOARES M, NEVES C, MARQUES I P, et al. Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography[J]. Br J Ophthalmol, 2017,101(1): 62-68. DOI: 10.1136/bjophthalmol-2016-309424.

更新日期/Last Update: 2018-05-30