[1]李龙坤,杨振兴.尿源性干细胞的特性及其在泌尿系统疾病治疗中的应用进展[J].第三军医大学学报,2018,40(04):277-281.
 LI Longkun,YANG Zhenxing.Characteristics and Application of urine-derived stem cells in treatment of urological diseases[J].J Third Mil Med Univ,2018,40(04):277-281.
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尿源性干细胞的特性及其在泌尿系统疾病治疗中的应用进展(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第04期
页码:
277-281
栏目:
专家述评
出版日期:
2018-02-28

文章信息/Info

Title:
Characteristics and Application of urine-derived stem cells in treatment of urological diseases
作者:
李龙坤杨振兴
陆军军医大学(第三军医大学)第二附属医院泌尿外科
Author(s):
LI Longkun YANG Zhenxing

Department of Urology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China

关键词:
尿源性干细胞泌尿系统疾病治疗
Keywords:
urine-derived stem cells urology disease treatment
分类号:
R329.2;R690.5
文献标志码:
A
Abstract:

Urine-derived stem cells (hUSCs) are stem cells isolated from adult urine with proliferation and differentiation potentials. With much convenience to obtain in a minimally invasive manner and virtually no immunogenicity, these cells can be widely used in regenerative medicine and tissue engineering. In recent years, increasing studies were reported to use hUSCs in repairing urinary tract injury with favorable outcomes, demonstrating bright prospects for clinical application of these cells. Herein we review the current progress in the application of USCs in models of urinary system disease and assess the potentials and therapeutic mechanisms of these cells.

参考文献/References:

[1]LE BLANC K, RASMUSSON I, SUNDBERG B, -et al. Treatment of severe acute graftversushost disease with third party haploidentical mesenchymal stem cells [J]. Lancet, 2004, 363(9419): 1439-1441. DOI: 10.1016/S0140-6736(04)16104-7.
[2]WU Y, CHEN L, SCOTT P G, et al. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis [J]. Stem Cells, 2007, 25(10): 2648-2659. DOI: 10.1634/stemcells.20070226.
[3]ZHANG Y, MCNEILL E, TIAN H, et al. Urine derived cells are a potential source for urological tissue reconstruction [J]. J Urol, 2008, 180(5): 2226-2233. DOI: 10.1016/j.juro.2008.07.023. 
[4]QIN D, LONG T, DENG J, et al. Urine-derived stem cells for potential use in bladder repair[J]. Stem Cell Res Ther, 2014, 5(3): 69. DOI: 10.1186/scrt458. 
[5]DONG X, ZHANG T, LIU Q, et al. Beneficial effects of urinederived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells[J]. Mol Cell Endocrinol, 2016, 427: 21-32. DOI: 10.1016/j.mce.2016.03.001. 
[6]LI J, LUO H, DONG X, et al. Therapeutic effect of urinederived stem cells for protamine/lipopolysaccharideinduced interstitial cystitis in a rat model[J]. Stem Cell Res Ther, 2017, 8(1): 107. DOI: 10.1186/s13287-017- 0547-9. 
[7]LI L, ZHANG D, LI P, et al. Virus integration and genome influence in approaches to stem cell based therapy for androurology[J]. Adv Drug Deliv Rev, 2015, 82-83: 12-21. DOI: 10.1016/j.addr.2014.10.012. 
[8]张腾, 董兴有, 刘骞, 等. 尿源干细胞促进脊髓损伤后神经源性膀胱恢复[J]. 第三军医大学学报, 2016, 38(10): 1073-1077. DOI: 10.16016/j.10005404.201512060.
ZHANG T, DONG X Y, LIU Q, et al. Effect of urinederivedstem cell transplantation on recovery of neurogenic bladder in rats after spinal cord injury[J]. J Third Mil Med Univ, 2016, 38(10): 1073-1077. DOI: 10.16016/j.10005404.201512060. 
[9]SCHOSSERER M, REYNOSO R, WALLY V, et al. Urine is a novel source of autologous mesenchymal stem cells for patients with epidermolysis bullosa[J]. BMC Res Notes, 2015, 8: 767. DOI: 10.1186/s1310401516867.〖
[10]GAO P, HAN P, JIANG D, et al. Effects of the donor age on proliferation, senescence and osteogenic capacity of human urinederived stem cells[J]. Cytotechnology, 2017, 69(5): 751-763. DOI: 10. 1007/s1061601700845. 
[11]CHUN S Y, KIM H T, LEE J S, et al. Characterization of urinederived cells from upper urinary tract in patients with bladder cancer[J]. Urology, 2012, 79(5): 1186-1181. DOI: 10.1016/j.urology.2011. 12.034. 
[12]LANG R, LIU G, SHI Y, et al. Selfrenewal and differentiation capacity of urinederived stem cells after urine preservation for 24 hours[J]. PLoS ONE, 2013, 8(1): e53980. DOI: 10.1371/journal.pone.0053980. 
[13]HE W, ZHU W, CAO Q, et al. Generation of mesenchymal〖JP〗like stem cells from urine in pediatric patients[J]. Transplant Proc, 2016, 48(6): 2181-2185. DOI: 10.1016/j.transproceed.2016.02. 078. 
[14]FLORES I, CAYUELA M L, BLASCO M A. Effects of telomerase and telomere length on epidermal stem cell behavior[J]. Science, 2005, 309(5738): 1253-1256. DOI: 10.1126/science.1115025. 
[15]BHARADWAJ S, LIU G, SHI Y, et al. Multipotential differentiation of human urinederived stem cells: potential for therapeutic applications in urology[J]. Stem Cells, 2013, 31(9): 1840-1856. DOI: 10.1002/stem.1424. 
[16]GUAN J J, NIU X, GONG F X, et al. Biological characteristics of humanurinederived stem cells: potential for cellbased therapy in neurology[J]. Tissue Eng Part A, 2014, 20(13-14): 1794-1806. DOI: 10.1089/ten.TEA.2013.0584. 
[17]KANG H S, CHOI S H, KIM B S, et al. Advanced properties of urine derived stem cells compared to adipose tissue derived stem cells in terms of cell proliferation, immune modulation and multi differentiation [J]. J Korean Med Sci, 2015, 30(12): 1764-1776. DOI: 10.3346/jkms.2015.30.12.1764.
[18]QIN H, ZHU C, AN Z, et al. Silver nanoparticles promote osteogenic differentiation of human urinederived stem cells at noncytotoxic concentrations[J]. Int J Nanomedicine, 2014, 9: 2469-2478. DOI: 10.2147/IJN.S59753.
[19]GUAN J, ZHANG J, GUO S, et al. Human urinederived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/βcatenin signaling pathway[J]. Biomaterials, 2015, 55: 1-11. DOI: 10.1016/j.biomaterials.2015.03.029. 
[20]GUAN J, ZHANG J, ZHU Z, et al. Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urinederived stem cells[J]. Stem Cell Res Ther, 2015, 6: 5. DOI: 10.1186/scrt539. 
[21]XUE Y, CAI X, WANG L, et al. Generating a nonintegrating human induced pluripotent stem cell bank from urinederived cells[J]. PLoS ONE, 2013, 8(8): e70573. DOI: 10.1371/journal.pone. 0070573. 
[22]CHEN Y, LUO R, XU Y, et al. Generation of systemic lupus erythematosusspecific induced pluripotent stem cells from urine[J]. Rheumatol Int, 2013, 33(8): 2127-2134. DOI: 10.1007/s0029601327045. 
[23]HOU J, WANG X, ZHANG S, et al. Generation and characterization of human cryptorchidspecific induced pluripotent stem cells from urine[J]. Stem Cells Dev, 2013, 22(5): 717-725. DOI: 10.1089/scd.2012.0260. 
[24]GUAN X, MACK D L, MORENO C M, et al. Dystrophindeficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery[J]. Stem Cell Res, 2014, 12(2): 467-480. DOI: 10.1016/j.scr.2013.12.004.
[25]JOUNI M, SITAYEB K, ESSALAHLAMOUREUX Z, et al. Toward personalized medicine: using cardiomyocytes differentiated from urinederived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome[J]. J Am Heart Assoc, 2015, 4(9): e002159. DOI: 10.1161/JAHA.115.002159. 
[26]WANG C, HEI F, JU Z, et al. Differentiation of urinederived human induced pluripotent stem cells to alveolar type Ⅱ epithelial cells[J]. Cell Reprogram, 2016, 18(1): 30-36. DOI: 10.1089/cell.2015.0015. 
[27]M LEE Y, ZAMPIERI B L, SCOTTMCKEAN J J, et al. Generation of integrationfree induced pluripotent stem cells from urinederived cells isolated from individuals with down syndrome[J]. Stem Cells Transl Med, 2017, 6(6): 1465-1476. DOI: 10.1002/sctm.160128. 
[28]MIZUTANI E, TORIKAI K, WAKAYAMA S, et al. Generation〖JP〗 of cloned mice and nuclear transfer embryonic stem cell lines from urinederived cells [J]. Sci Rep, 2016, 6: 23808. DOI: 10.1038/srep23808.
[29]BODIN A, BHARADWAJ S, WU S, et al. Tissueengineered conduit using urinederived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion[J]. Biomaterials, 2010, 31(34): 8889-8901. DOI: 10.1016/j.biomaterials.2010.07.108. 
[30]WU S, LIU Y, BHARADWAJ S, et al. Human urinederived stem cells seeded in a modified 3D porous small intestinal submucosa scaffold for urethral tissue engineering[J]. Biomaterials, 2011, 32(5): 1317-1326. DOI: 10.1016/j.biomaterials. 2010.10.006. 
[31]LIU G, WANG X, SUN X, et al. The effect of urinederived stem cells expressing VEGF loaded in collagen hydrogels on myogenesis and innervation following after subcutaneous implantation in nude mice[J]. 〖JP2〗Biomaterials, 2013, 34(34): 8617-8629. DOI: 10.1016/j.biomaterials.2013.〖JP〗07.077. 
[32]FU Y, GUAN J, GUO S, et al. Human urinederived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis[J]. J Transl Med, 2014, 12: 274. DOI: 10.1186/s1296701402742. 〖HJ1.75mm〗
[33]TIAN S F, JIANG Z Z, LIU Y M, et al. Human urine derived stem cells contribute to the repair of ischemic acute kidney injury in rats[J]. Mol Med Rep, 2017, 16(4): 5541-5548. DOI: 10.3892/mmr.2017.7240. 
[34]AICHER W K, HART M L, STALLKAMP J, et al. Towards a treatment of stress urinary incontinence: Application of mesenchymal stromal cells for regeneration of the sphincter muscle [J]. J Clin Med, 2014, 3(1): 197-215. DOI: 10.3390/jcm3010197. 
[35]OUYANG B, SUN X, HAN D, et al. Human urinederived stem cells alone or geneticallymodified with FGF2 improve type 2 diabetic erectile dysfunction in a rat model[J]. PLoS ONE, 2014, 9(3): e92825. DOI: 10.1371/journal.pone.0092825. 
[36]LEE J N, CHUN S Y, LEE H J, et al. Human urine derived stem cells seeded surface modified composite scaffold grafts for bladder reconstruction in a rat model [J]. J Korean Med Sci, 2015, 30(12): 1754-1763. DOI: 10.3346/jkms. 2015.30.12.1754.
[37]JIANG Z Z, LIU Y M, NIU X, et al. Exosomes secreted by human urinederived stem cells could prevent kidney complications from type I diabetes in rats [J]. Stem Cell Res Ther, 

更新日期/Last Update: 2018-02-28