[1]刘微,冉柳毅,靳佳佳,等.五羟色胺受体基因和五羟色胺转运体基因交互作用与青年人自杀未遂行为的关系[J].第三军医大学学报,2018,40(12):1115-1119.
 LIU Wei,RAN Liuyi,JIN Jiajia,et al.Interaction between 5-hydroxytryptamine receptor 1B gene and serotonin transporter gene is potentially associated with suicide attempts in youths[J].J Third Mil Med Univ,2018,40(12):1115-1119.
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五羟色胺受体基因和五羟色胺转运体基因交互作用与青年人自杀未遂行为的关系(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第12期
页码:
1115-1119
栏目:
临床医学
出版日期:
2018-06-30

文章信息/Info

Title:
Interaction between 5-hydroxytryptamine receptor 1B gene and serotonin transporter gene is potentially associated with suicide attempts in youths
作者:
刘微冉柳毅靳佳佳王苏亚吴同艾明陈建梅况利
重庆医科大学附属大学城医院心理卫生中心;重庆医科大学附属第一医院心理卫生中心
Author(s):
LIU Wei RAN Liuyi JIN Jiajia WANG Suya WU Tong AI Ming CHEN Jianmei KUANG Li

Center for Mental Health Services, University-Town Hospital of Chongqing Medical University, Chongqing, 401331; 2Center for Mental Health Services, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

关键词:
青年人自杀未遂基因基因交互作用五羟色胺受体五羟色胺转运体
Keywords:
youths attempted suicide gene-gene interaction 5-hydroxytryptamine receptor 1B 5-hydroxytryptamine transporter
分类号:
R181.23;R394.1;R395.6
文献标志码:
A
摘要:

目的     探讨五羟色胺(5-hydroxy tryptamine,5-HT)系统中五羟色胺1B受体(5-hydroxy tryptamine 1B receptor,5HTR1B)基因和五羟色胺转运体(5-hydroxy tryptamine  transporter,5HTT)基因的交互作用对青年人自杀未遂行为的影响。方法选取5HTR1B基因rs6296和5HTT基因rs1042173、rs140701、rs2066713多态性位点,采用iMLDRTM 多重SNP分型技术对病例组(70例自杀未遂青年人)和对照组(112例健康青年人)进行检验。采用广义多因子降维法(generalized multifactor dimensionality reduction,GMDR)分析基因基因交互作用。结果5HTT基因rs1042173、rs140701、rs2066713的基因型频率和等位基因频率在病例组和对照组中分布差异无统计学意义(P>0.05)。5HTR1B rs6296等位基因频率在病例组和对照组中分布差异无统计学意义(P>0.05),5HTR1B rs6296病例组基因型频率(CC 31.4%、CG 31.4%、GG 37.1%)和对照组基因型频率(CC 19.8%、CG 53.2%、GG 27%)分布差异有统计学意义(χ2 =8.327,P=0.016),经Bonferroni校正后差异无统计学意义(P>0.05)。GMDR分析结果显示,5HTT与5HTR1B基因交互作用存在于两位点模型(rs1042173、rs6296,测试样本精确度0.6185,交叉验证一致性10/10,P值为0.0210~0.0220)、三位点模型(rs1042173、rs140701、rs6296,测试样本精确度0.644 5,交叉验证一致性10/10,P值为0.003 0~0.004 0)、四位点模型(rs1042173、rs140701、rs2066713、rs6296,测试样本精确度0.6120,交叉验证一致性9/10,P值为0.0320~0.0330)。结论5HTR1B和5HTT基因存在交互作用,并可能与青年人的自杀未遂行为有关。

Abstract:

ObjectiveTo explore the interaction between 5-hydroxytryptamine (5-HT) receptor 1B (5-HTR1B) gene and 5HT transporter (5-HTT) gene in the 5-HT system and investigate how this interaction is associated with attempted suicide in youths. MethodsiMLDRTM multiplex single nucleotide polymorphism (SNP) typing was used to examine the SNPs at one locus (rs6296) of 5HTR1B gene and 3 loci (rs1042173, rs140701 and rs2066713) of 5-HTT gene in 70 youths (aged 15-24 years) with attempted suicide (case group) and 112 age-matched healthy subjects (control group). The interaction between 5-HTR1B gene and 5HTT gene was analyzed using generalized multifactor dimensionality reduction (GMDR). ResultsNo significant differences were found between the case and control groups in the genotype frequencies or allele frequencies at the loci rs1042173, rs140701, or rs2066713 in 5HTT gene (P>0.05). The allele frequency of rs6296 in 5HTR1B gene was similar between the 2 groups (P>0.05), but the CC, CG, and GG genotype frequencies of 5HTR1B rs6296 differed significantly between the case group (31.4%, 31.4%, and 37.1%, respectively) and the control group (19.8%, 53.2%, and 27%, respectively) (Chi-square=8.327, P=0.016); these differences, however, were not statistically significant after Bonferroni correction (P>0.05). GMDR analysis indicated the presence of interactions between 5-HTT gene and 5-HTR1B gene in the two-site model (rs1042173 and rs6296) with a test accuracy of 0.6185 and  a cross validation consistency of 10/10 (P=0.021 0-0.022 0), in the three-site model (rs1042173, rs140701, and rs6296) with a test accuracy of 0.644 5 and cross validation consistency of 10/10 (P=0.0030-0.0040) as well as in the four-site model (rs1042173, rs140701, rs2066713, and rs6296) with a test accuracy of 0.6120 and a cross validation consistency of 10/10 (P=0.0320-0.0330). ConclusionThere are interactions between 5-HTR1B gene and 5-HTT gene, which may be associated with attempted suicide in youths.

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相似文献/References:

[1]操军,艾明,况利,等.重庆市大学生自杀未遂及其影响因素的调查分析[J].第三军医大学学报,2013,35(24 ):2692.
 Cao Jun,Ai Ming,Kuang Li,et al.Survey on suicide attempts and influencing factors of college students in Chongqing[J].J Third Mil Med Univ,2013,35(12):2692.
[2]刘耀,况利,艾明,等.生活事件、社会支持及生命质量与大学生自杀未遂的关系[J].第三军医大学学报,2014,36(11):1138.
 Liu Yao,Kuang Li,Ai Ming,et al.Correlation of life events, social support and quality of life with suicide attempts among college students[J].J Third Mil Med Univ,2014,36(12):1138.

更新日期/Last Update: 2018-07-03