[1]张扬,李春花,王益卓,等.随机对照研究分阶段口服低浓度复方聚乙二醇电解质溶液的结肠肠道准备效果[J].第三军医大学学报,2018,40(04):345-349.
 ZHANG Yang,LI Chunhua,WANG Yizhuo,et al.Effect of staged oral administration of low-concentration polyethylene glycol electrolyte solution for bowel preparation: a randomized controlled trial[J].J Third Mil Med Univ,2018,40(04):345-349.
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随机对照研究分阶段口服低浓度复方聚乙二醇电解质溶液的结肠肠道准备效果(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第04期
页码:
345-349
栏目:
临床医学
出版日期:
2018-02-28

文章信息/Info

Title:
Effect of staged oral administration of low-concentration polyethylene glycol electrolyte solution for bowel preparation: a randomized controlled trial
作者:
张扬李春花王益卓于劲林辉赵国策
陆军军医大学(第三军医大学)第二附属医院消化内科
Author(s):
ZHANG Yang LI Chunhua WANG Yizhuo YU Jin LIN Hui ZHAO Guoce

Department of Gastroenterology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China

关键词:
结肠镜低浓度复方聚乙二醇电解质Boston肠道准备量表
Keywords:
colonoscopy low concentration compound polyethylene glycol electrolyte Boston bowel preparation scale
分类号:
R322.45;R619;R979.9
文献标志码:
A
摘要:

目的    采用随机对照试验评价3 L低浓度分阶段口服复方聚乙二醇电解质溶液(polyethylene glycol electrolyte,PEG)在结肠镜检查前的肠道准备的效果和不良反应。方法    以2017年2月1日至2017年5月31日在本院消化科拟行结肠镜检查的全部患者300例作为研究对象,采用计算机随机数字表将其分为A组(3 L低浓度分阶段组)和B组(2 L传统浓度组),结肠镜检查医师和护士盲法采用Boston肠道准备量表(boston bowel preparation scale, BBPS)进行评分和询问记录不良反应发生情况。结果    两组患者的平均年龄、性别比例、身高、体质量和文化程度等一般特征差异无统计学意义(P>0.05)。A组肠道准备有效率(BBPS≥5分)和优良率(BBPS≥8分)分别为94.7%(142/150)、62.7%(94/150),均显著高于B组的79.3%(119/150)和38.0%(57/150)(P<0.01);A组总体不良反应发生发生率为14.0%(21/150)显著低于B组的32.0%(P<0.01)。结论    3 L低浓度PEG分阶段口服方案具有较好的肠道清洁效果且副作用发生率相对较低。

Abstract:

Objective    To evaluate the effect and adverse reactions of staged oral administration of low-concentration polyethylene glycol electrolyte (PEG) solution in a volume of 3 L for intestinal preparation before colonoscopy.   Methods    From February 1, 2017 to May 31, 2017, 300 patients undergoing elective colonoscopy in our department were randomized for bowel preparation with either staged oral administration of 3 L low-concentration PEG solution (group A) or with one-stage oral administration of 2 L PEG solution at the conventional concentration (group B). The colonoscopists and nurses, who were blinded to the randomization of the patients, assessed the Boston intestinal preparation score (BBPS) and recorded the occurrence of adverse reactions in the patients. Results    The average age, gender ratio, height, body weight and education level were all similar between the 2 groups (P>0.05). In group A, the rates of good bowel preparation effect (BBPS≥5) and excellent effect (BBPS≥8) were 94.6% (142/150) and 62.7% (94/150), significantly higher than the rates of 79.3% (119/150) and 38.0% (57/150) in group B, respectively (P<0.01). Adverse reactions occurred in 14.0% (21/150) of the patients in group A, a rate significantly lower than that in group B (32.0%, P<0.01). Conclusion    Staged oral administration of 3 L low-concentration PEG solution produces better bowel cleaning effect with lowered adverse reactions compared with the conventional bowel preparation method.

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更新日期/Last Update: 2018-03-03