[1]陈元利,徐颖.615例住院早产儿出血的危险因素分析[J].第三军医大学学报,2017,39(16):1669-1672.
 CHEN Yuanli,XU Ying.Risk factors for hemorrhage in hospitalized premature infants: analysis of 615 cases[J].J Third Mil Med Univ,2017,39(16):1669-1672.
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615例住院早产儿出血的危险因素分析(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
39卷
期数:
2017年第16期
页码:
1669-1672
栏目:
临床医学
出版日期:
2017-08-30

文章信息/Info

Title:
Risk factors for hemorrhage in hospitalized premature infants: analysis of 615 cases
作者:
陈元利徐颖
重庆医科大学附属儿童医院麻醉科,重庆市急救医疗中心麻醉科
Author(s):
CHEN Yuanli XU Ying

Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Chongqing, 400014; Department of Anesthesiology, Chongqing Emergency Medical Center, Chongqing, 400014, China
 

关键词:
早产儿出血危险因素
Keywords:
premature infants hemorrhage risk factors
分类号:
R181.32;R442.7;R722.6
文献标志码:
A
摘要:

目的      分析早产儿出血的危险因素。方法     通过收集整理2014年1月至2016年1月重庆医科大学附属儿童医院615例住院早产儿的临床资料(基本资料、围产因素、出血表现等)和相关实验室检查(凝血5项、血小板计数、白细胞计数),根据临床诊断是否有出血分为出血组和未出血组,先对两组患儿的临床资料及相关实验室检查进行单因素分析,然后对经过单因素分析有显著意义的自变量进行多因素Logistic回归分析。结果     单因素分析发现两组患儿之间的胎龄、是否有窒息复苏史、白细胞计数、血小板计数和凝血5项中的凝血酶原时间和纤维蛋白原的差异有统计学意义(P<0.05,P<0.01)。多因素Logistics回归分析结果显示两组间胎龄、是否有窒息复苏史、血小板计数、白细胞、纤维蛋白原值差异有统计学意义(P<0.05),胎龄、血小板计数和纤维蛋白原升高是保护因素,窒息复苏史、白细胞高是危险因素。结论       早产儿胎龄低、有窒息复苏史、白细胞高、血小板计数和纤维蛋白原低均要警惕有出血的风险。

Abstract:

Objective     To analyze the related risk factors for premature infant hemorrhage. Methods      A retrospective study was carried out on 615 hospitalized premature newborns in the Children’s Hospital from January 2014 to January 2016. Their clinical data (including basic information, perinatal factors, and bleeding) and laboratory results (coagulation indexes, platelet count, and white blood cell count) were collected. The infants were divided into 2 groups according to having or having not hemorrhage. Univariate analysis and  logistic regression analysis were used to identify independent variables of considerable significance. Results     Univariate analysis revealed that significant differences were found in prothrombin time (PT) and fibrinogen (FIB) between the 2 groups (P<0.05, P<0.01), but not in the gestational age, asphyxia history, white blood cell count, and platelet count. While multivariate logistic regression analysis showed that there were significant differences in gestational age, asphyxia resuscitation history, platelet count, white blood cell count and FIB value between the 2 groups (P<005). Longer gestational age, and higher platelet count and FIB value were protective factors, while asphyxia resuscitation history and higher white blood cell count were risk factors. Conclusion      Short gestational age, history of asphyxia resuscitation, high white blood cell count, and low platelet count and FIB value are risk factors for premature infants hemorrhage.

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更新日期/Last Update: 2017-08-23