[1]张丹,陈康,谯智慧,等.表观弥散系数与非小细胞肺癌预后分子生物学指标的相关性分析[J].第三军医大学学报,2017,39(09):913-918.
 Zhang Dan,Chen Kang,Qiao Zhihui,et al.Correlation of apparent diffusion coefficient with common prognostic molecular biological indicators of non-small cell lung cancer[J].J Third Mil Med Univ,2017,39(09):913-918.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
39卷
期数:
2017年第09期
页码:
913-918
栏目:
临床医学
出版日期:
2017-05-15

文章信息/Info

Title:
Correlation of apparent diffusion coefficient with common prognostic molecular biological indicators of non-small cell lung cancer
作者:
张丹陈康谯智慧谢兵陈伟熊玮
第三军医大学西南医院:呼吸内科,放射科,老年科
Author(s):
Zhang Dan Chen Kang Qiao Zhihui Xie Bing Chen Wei Xiong Wei

Department of Respiratory Diseases, Department of Radiology,Department of Geriatrics, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China

关键词:
非小细胞肺癌弥散加权成像表观弥散系数磁共振成像
Keywords:
non-small cell lung cancer diffusion weighted imaging apparent diffusion coefficient magnetic resonance imaging
分类号:
R445.2; R446.8; R734.2
文献标志码:
A
摘要:

目的        探讨表观弥散系数(apparent diffusion coefficient,ADC)与非小细胞肺癌(nonsmall cell lung cancer,NSCLC)常见的预后分子生物学指标的相关性。方法      39例经病理证实为NSCLC的患者接受磁共振弥散加权成像(diffusion weighted imaging,DWI)检查,测量病变的ADC值。采用单因素方差分析及t检验分析不同生物学指标如血中癌胚抗原(cancer embryo antigen,CEA)、组织中Ki67、甲状腺转录因子1(thyroid transcription factor 1,TTF-1)、表皮生长因子受体(epidermal growth factor receptor,EGFR)之间ADC值的差异,采用Spearman相关系数分析ADC值与不同生物学指标的相关性。结果      不同生物学指标CEA、Ki67、TTF-1、EGFR之间的ADC值差异均有统计学意义(P<0.01),且ADC值与上述预后相关的生物学指标均存在负相关(CEA:r=-0.77,P<0.001,Ki67:r=-0.58,P<0.001,TTF-1:r=-0.47,P=0.003,EGFR:r=-0.40,P=0.012)。结论       ADC值与NSCLC常见的预后分子生物学指标CEA、Ki67、TTF-1、EGFR存在负相关关系,ADC值较低往往提示CEA与Ki67水平较高,表明TTF-1阳性及EGFR突变可能。

Abstract:

Objective       To analyze the correlation of apparent diffusion coefficient (ADC) with common prognostic molecular biological indicators of non-small cell lung cancer (NSCLC). Methods        Thirty-nine patients with histopathologically conformed NSCLC admitted in the Department of Respiratory Diseases from April 2015 to September 2016 were recruited in this study. All the patients underwent diffusion weighted imaging (DWI), ADCs were calculated based on DW images. Students’ t test and single factor analysis of variance were applied to analyze the differences of ADCs in biological indicators, serum cancer embryo antigen (CEA), positive rate of Ki67, thyroid transcription factor 1 (TTF-1), and epidermal growth factor receptor (EGFR). Spearman rank correlation was used to analyze the correlations of the ADCs with above indicators. Results        The ADCs in different indicators, such as CEA, Ki67, TTF-1 and EGFR were significantly different (P<0.01). Negative correlations were found between ADCs and above biological indicators (CEA: r=-0.77, P<0.001; Ki67: r=-0.58, P<0.001; TTF-1: r=-0.47, P=0.003; EGFR: r=-0.40, P=0.012). Conclusion       ADCs are negatively correlated with common prognostic indicators CEA, Ki67, TTF-1 and EGFR. Lower ADCs commonly suggest higher CEA and Ki67, which might predict positive TTF-1 and EGFR mutations.

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更新日期/Last Update: 2017-05-08