[1]林斌,张兴艳,王亮.体外冲击波调控免疫反应对ⅢB型CP/CPPS患者的疗效及其机制研究[J].第三军医大学学报,2017,39(14):1498-1452.
 LIN Bin,ZHANG Xingyan,WANG Liang.Effect of extracorporeal shock wave therapy combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome and the mechanism[J].J Third Mil Med Univ,2017,39(14):1498-1452.
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体外冲击波调控免疫反应对ⅢB型CP/CPPS患者的疗效及其机制研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
39卷
期数:
2017年第14期
页码:
1498-1452
栏目:
临床医学
出版日期:
2017-07-30

文章信息/Info

Title:
Effect of extracorporeal shock wave therapy combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome and the mechanism
作者:
林斌张兴艳王亮
金堂县第一人民医院(四川大学华西医院金堂医院)泌尿外科;重庆市肿瘤医院泌尿外科
Author(s):
LIN Bin1 ZHANG Xingyan1 WANG Liang

Department of Urology, Jintang Hospital of West China Hospital of Sichuan University/ First People’s Hospital of Jintang County, Chengdu, Sichuan Province, 610400; Department of Urology, Chongqing Tumor Hospital, Chongqing, 400037, China

关键词:
体外冲击波治疗炎症免疫反应慢性前列腺炎慢性盆腔疼痛综合征
Keywords:
extracorporeal shock wave therapy inflammation immune response chronic prostatitis chronic pelvic pain syndrome
分类号:
R392.32;R454.4;R697.33
文献标志码:
A
摘要:

目的探讨体外冲击波治疗(extracorporeal shock wave therapy,ESWT)对ⅢB型慢性前列腺炎(CP)/慢性盆腔疼痛综合征(CPPS)患者免疫反应的影响,并观察其疗效。方法收集2014年1月至2016年9月于我院就诊的120例CP/CPPS患者,采用随机数字表法分为试验组与对照组,各60例。对照组给予坦索罗辛治疗,试验组予ESWT+坦索罗辛治疗,两组均治疗4周。治疗后收集两组患者慢性前列腺炎症状评分(NIHCPSI),国际前列腺症状评分(IPSS),前列腺液中TNFα、IL6、卵磷脂小体及外周血中CD3+、CD4+、CD8+、CD4+CD25+、TGFβ1、CD4+CD25+Foxp3+的表达变化。结果治疗4周后,与对照组相比,试验组总体有效率明显提高(63.3% vs 93.3%,P<005);NIHCPSI评分(13.12±171 vs  23.16±1.33)和IPSS评分(8.23±2.28 vs 13.14±2.69)明显降低。在炎症和免疫影响方面,与对照组相比,试验组前列腺液中卵磷脂小体明显升高,炎性因子TNFα、IL1β水平明显降低;外周血中CD3+、CD4+、CD8+、CD4+CD25+、TGFβ1、CD4+CD25+Foxp3+表达均明显提高。结论ESWT治疗ⅢB型CP/CPPS安全有效,其可能的作用机制与提高患者的免疫功能、降低前列腺局部炎症应答有关。

Abstract:

ObjectiveTo investigate the effect of extracorporeal shock wave therapy (ESWT) combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and explore the possible mechanisms. MethodsA total of 120 patients with category ⅢB CP/CPPS were randomized into ESWT group and control group (n=60) to receive treatments with ESWT plus tamsulosin and tamsulosin alone, respectively. After 4 weeks of treatment, the improvements of clinical symptoms (NIHCPSI and IPSS score), levels of tumor necrosis factorα (TNFα), interleukin6 (IL6) and lecithin bodies in the prostatic fluid, and levels of CD3+, CD4+, CD8+, CD4+ CD25+, CD4+ CD25+ Foxp3+ cells and transforming growth factor (TGF)β1 in the peripheral blood were determined. ResultsAfter 4 weeks of treatment, the patients in ESWT group showed a significantly higher overall response rate than those in the control group (93.3% vs 63.3%, P<005) with and significantly decreased scores of NIHCPSI (13.12±1.71 vs  23.16±1.33) and IPSS (8.23±2.28 vs 13.14±2.69). Compared with those in the control group, the content of lecithin body was significantly increased and the levels of inflammatory factors TNFα and IL1 were significantly decreased in ESWT group; the contents of CD3+, CD4+, CD8+, CD4+CD25+, CD4+CD25+Foxp3+ cells and TGFβ1 level in peripheral blood were significantly increased in ESWT group. ConclusionESWT combined with tamsulosin is safe and effective for treatment of category ⅢB CP/CPPS possibly by improving the immune function and reducing the local inflammatory response in the prostate.

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更新日期/Last Update: 2017-07-24