[1]甄佳秀,杨正艳,左静,等.锶纳米羟基磷灰石原花青素复合涂膜对牙本质小管的封闭作用[J].第三军医大学学报,2017,39(07):622-627.
 Zhen Jiaxiu,Yang Zhengyan,Zuo Jing,et al.Sealing effect of procyanidins containing-strontium-substituted-hydroxyapatite composite varnish on dentinal tubules in vitro [J].J Third Mil Med Univ,2017,39(07):622-627.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
39卷
期数:
2017年第07期
页码:
622-627
栏目:
基础医学
出版日期:
2017-04-15

文章信息/Info

Title:
Sealing effect of procyanidins containing-strontium-substituted-hydroxyapatite composite varnish on dentinal tubules in vitro 
作者:
甄佳秀杨正艳左静周智
重庆医科大学附属口腔医院:预防口腔科,口腔疾病与生物医学重庆市重点实验室,重庆市高校市级口腔生物医学工程重点实验室
Author(s):
Zhen Jiaxiu Yang Zhengyan Zuo Jing Zhou Zhi

Department of Preventive Stomatology, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Key Laboratory of Oral Biomedical Engineering of Higher Education, Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China

关键词:
原花青素渗透型丙烯酸树脂涂膜牙本质过敏锶纳米羟基磷灰石
Keywords:
procyanidins eudragit RL100 varnish dentine hypersensitivity strontium-substitutedhydroxyapatite
分类号:
R282.71; R781.2; R783.1
文献标志码:
A
摘要:

目的      检测自主合成的锶纳米羟基磷灰石原花青素(strontium-substituted-hydroxyapatite varnish,SrHAP-PA)复合涂膜对牙本质小管的封闭作用。 方法      首先构建牙本质敏感体外研究模型,并在模拟人口腔环境的条件下检测SrHAP-PA复合涂膜对牙本质小管的封闭作用,用扫描电镜观察循环结束后各组牙本质小管的封闭情况,X线能谱分析牙本质表面元素变化,记录各组傅里叶红外光谱,并用激光共聚焦扫描显微镜观察药品进入牙本质小管情况。结果     成功构建了体外牙本质敏感的模型,并且在扫描电子显微镜下观察到SrHAP-PA复合涂膜能有效地封闭牙本质小管,X线能谱分析检测发现SrHAP-PA复合涂膜促进矿化物的形成,激光共聚焦扫描显微镜观察到该涂膜能快速进入到牙本质小管中,且能保存较长时间。结论      以SrHAP-PA复合物为有效成分的涂膜材料能有效封闭牙本质小管。

Abstract:

Objective     To investigate the occlusion effect of a novel nanoscaled procyanidins containingstrontium-substituted-hydroxyapatite varnish (SrHAP-PA) on the dentin tubules in vitro.  Methods      The model of dentin hypersensitivity was established in cow central incisors, then the sealing effect of SrHAP-PA varnish was examined on dentinal tubules under simulated human oral environment. Fluorine coating was used for the positive control group, and blank group served as negative control. Morphological alterations were observed by scanning electron microscopy (SEM). Energy dispersive X-ray microanalysis (EDX) were used to analyze the changes of element quality on dentin surface. Fourier transform infrared spectroscopy (FTIR) was carried out and confocal laser scanning microscopy was used to observe the dentin tubules. Results     The dentin-hypersensitivity model was successfully constructed. The SrHAP-PA varnish was observed to effectively occlude the dentinal tubules by SEM. EDX showed that the SrHAP-PA composite film promoted remineralization and FTIR displayed that the SrHAP-PA varnish can quickly enter into the dentinal tubules, and save for a long time in the simulation of the oral environment. Conclusion      The SrHAP-PA complex as the active ingredient of the coating material can effectively seal the dentinal tubules.

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更新日期/Last Update: 2017-04-07