[1]王晓果,陈婷,刘焕凤,等.小剂量地西他滨在异基因造血干细胞移植后早期复发及cGVHD治疗中的作用[J].第三军医大学学报,2016,38(12):1362-1365.
 Wang Xiaoguo,Chen Ting,Liu Huanfeng,et al.Role of small-dose decitabine in treatment of early recurrence and chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation[J].J Third Mil Med Univ,2016,38(12):1362-1365.
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小剂量地西他滨在异基因造血干细胞移植后早期复发及cGVHD治疗中的作用(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
38卷
期数:
2016年第12期
页码:
1362-1365
栏目:
专题报道
出版日期:
2016-06-30

文章信息/Info

Title:
Role of small-dose decitabine in treatment of early recurrence and chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation
作者:
王晓果陈婷刘焕凤邓天霞刘俊张诚张曦孔佩艳
第三军医大学新桥医院全军血液病中心
Author(s):
Wang XiaoguoChen TingLiu HuanfengDeng TianxiaLiu JunZhang ChengZhang XiKong Peiyan

Center of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China

关键词:
地西他滨异基因造血干细胞移植移植物抗宿主病
Keywords:
decitabine allogeneic hematopoietic stem cell transplantation graft versus host disease
分类号:
R617; R730.53; R733.71
文献标志码:
A
摘要:

目的      分析小剂量地西他滨(decitabine/dacogen,DAC)治疗异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)后慢性移植物抗宿主病(chronic graft versus host disease,cGVHD)患者的转归情况。      方法      收集2013年6月25日至2015年7月7日我院行allo-HSCT术后早期复发及发生cGVHD,并接受小剂量DAC治疗的4例患者,包括急性髓系白血病(acute myeloid leukemia,AML)3例,骨髓增生异常综合征(myelodysplastic syndrome,MDS)1例。对其诊断、移植方式、cGVHD分型及评分、以及DAC治疗后转归进行分析。      结果      4例接受小剂量DAC的患者,cGVHD症状减轻,无严重的血液学毒性。1例因严重肺部感染放弃治疗,3例目前病情稳定。      结论      小剂量DAC可减轻allo-HSCT术后cGVHD症状,改善患者生存质量,并对早期复发的控制有一定的效果。

Abstract:

Objective      To analyze the outcomes of 4 cases of chronic graft versus host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) treated by small-dose decitabine/dacogen (DAC).       Methods      Clinical data of 4 patients who have cGVHD effects and early recurrence after allo-HSCT,and then received small-dose DAC treatment in our hospital from June 25,2013 to July 7,2015 were collected in this study. Three of them were acute myeloid leukemia (AML), and the other 1 case was myelodysplastic syndrome (MDS).Their diagnosis, transplantation methods, types and scores of cGVHD, and treatment outcome were retrospectively analyzed.       Results      All 4 patients had decreased effects of cGVHD and had no severe hematologic toxicity after small-dose DCA therapy.One of the patients gave up the treatment because of pulmonary infection, and the other 3 ones were in stable disease stage till now.       Conclusion      Small-dose DAC therapy alleviates cGVHD after allo-HSCT, improves quality of life in the patients,and has certain effect on controlling early recurrence.

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更新日期/Last Update: 2016-06-07