[1]陈高亮,邓晓洪,欧平,等.伐地那非降阶梯治疗男性勃起功能障碍的效果分析[J].第三军医大学学报,2015,37(15):1505-1507.
 Chen Gaoliang,Deng Xiaohong,Ou Ping,et al.Vardenafil step-down therapy for male erectile dysfunction: a report of 65 cases[J].J Third Mil Med Univ,2015,37(15):1505-1507.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
37卷
期数:
2015年第15期
页码:
1505-1507
栏目:
论著
出版日期:
2015-08-15

文章信息/Info

Title:
Vardenafil step-down therapy for male erectile dysfunction: a report of 65 cases
作者:
陈高亮邓晓洪欧平郑军王元中李世健
重庆市中山医院泌尿外科
Author(s):
Chen Gaoliang Deng Xiaohong Ou Ping Zheng Jun Wang Yuanzhong Li Shijian

Department of Urology, Chongqing Zhongshan Hospital, Chongqing, 400013, China

关键词:
伐地那非男性勃起功能障碍疗效副反应
Keywords:
vardenafil male erectile dysfunction clinical efficiency Adverse event
分类号:
R698.05; R969.4; R971.94
文献标志码:
A
摘要:

目的      观察逐渐降低伐地那非剂量治疗男性勃起功能障碍(erectile dysfunction,ED)的疗效。      方法      65例初治ED患者,分别给予20、10、5 mg(A、B、C 3个阶段)的伐地那非降阶梯序贯疗法,每个阶段治疗时间为1个月。      结果      3阶段组患者治疗后国际勃起功能指数(international index of erectile function,IIEF) 均高于治疗前(P<0.05)。A、 B、C 3阶段患者日记记录插入成功率分别为78.1%、75.9%、69.1%;完成性交的成功率分别为74.9%、70.7%、66.9%,均高于治疗前(P<0.05)。A、B、C 3阶段药物副反应发生率分别为56.9%、29.2%、26.2%,A阶段明显高于B、C阶段(P<0.05)。      结论      伐地那非减低到中、低剂量时,能够在保证疗效的基础上,显著减少药物副反应的发生。

Abstract:

Objective       To observe the clinical efficiency  of gradually reducing doses of vardenafil for the treatment of male erectile dysfunction.       Methods        Sixty-five treatment-naive patients with erectile dysfunction admitted in our hospital from January 2011 to June 2014 who received step-down therapy were enrolled in this study. They were given oral vardenafil 20 mg/time (phase A), 10 mg /time (phase B), and 5 mg/time (phase C), each phase lasting for one month.       Results      After the treatment, international index of erectile function (IIEF) of all phases was significantly higher than that before treatment (P<0.05). Penile penetration success rates of the 3 phases were 78.1%, 75.9%, and 69.1%, respectively. The success rates of sexual intercourse were 74.9%, 70.7%, and 66.9%, which were significantly higher than those before treatment (P<0.05). The rates of drug side effects of the 3 phases were 56.9%, 29.2%, and 26.2%, respectively, and compared with phase B and phase C, phase A had higher drug side effects, with statistically significant difference (P<0.05).       Conclusion       Step-down therapy of vardenafil is effective for the treatment of erectile dysfunction with few drug side effects.

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更新日期/Last Update: 2015-08-19