[1]童强,王慧,管凌志,等.艾塞那肽对2型糖尿病患者的C肽影响及疗效观察[J].陆军军医大学学报(原第三军医大学学报),2014,36(15):1604-1606.
　Tong Qiang,Wang Hui,Guan Lingzhi,et al.Clinical effects of exenatide in treatment of type 2 diabetes and on expression of C-peptide[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(15):1604-1606.
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艾塞那肽对2型糖尿病患者的C肽影响及疗效观察(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
36卷
期数:
2014年第15期
页码:
1604-1606
栏目:
论著
出版日期:
2014-08-15

文章信息/Info

Title:
Clinical effects of exenatide in treatment of type 2 diabetes and on expression of C-peptide
作者:
童强; 王慧; 管凌志; 王小翠; 赵渝
重庆医科大学附属第一医院血管外科；第三军医大学新桥医院内分泌科
Author(s):
Tong Qiang;  Wang Hui;  Guan Lingzhi; Wang Xiaocui; Zhao Yu
Departmen of Vascular Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400042; Department of Endocrinology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
关键词:
GLP-1受体激动剂; 艾塞那肽; 2型糖尿病
Keywords:
glucagon-like peptide-1 receptor;  exenatide;  type 2 diabetes
分类号:
R587.1; R969.4; R977.15
文献标志码:
A
摘要:
目的      观察艾塞那肽对2型糖尿病患者C肽的影响及临床疗效。      方法        选取2012年1月至2013年6月在新桥医院内分泌科住院的2型糖尿病患者78例，分为治疗组（n=39），给予二甲双胍联合艾塞那肽治疗，包括男性16例，女性23例，年龄（49.0±6.0）岁；对照组（n=39），给予二甲双胍联合甘精胰岛素治疗，包括男性21例，女性18例，年龄（50.1±5.9）岁。两组均治疗16周。监测并分析两组治疗前后空腹及餐后2 h C肽、空腹血糖（fasting blood glucose，FBG）、餐后2 h血糖（2-hour postprandial blood glucose，2hPG）、糖化血红蛋白（glycosylated hemoglobin，HbA1c）、体质量指数（BMI）等相关指标的变化。      结果       治疗16周后治疗组空腹及餐后2 h C肽水平[（2.34±0.51）、（2.66±0.99）ng/mL]均较治疗前[（1.89±0.63）、（1.09±0.46）ng/mL]有所增高（P<0.05），但对照组C肽治疗前后无明显变化（P>0.05）；两组患者治疗后的FBG、2hPG、HbA1c[治疗组治疗后分别为（6.94±0.75）、（9.98±0.85）mmol/L，（6.87±0.89）%]均较治疗前[治疗组治疗前分别为（10.06±1.98）、（12.3±0.75）mmol/L，（8.89±1.15）%]有所降低（P<0.05），且两组之间差异无统计学意义（P>0.05）；两组患者体质量、腹围及BMI均较治疗前有所下降，治疗组降低更明显（P<0.05）。      结论        艾塞那肽联合二甲双胍在提高2型糖尿病患者的C肽水平的同时能够降低患者的血糖、HbA1c、体质量、腹围及BMI。
Abstract:
Objective       To determine the effects of exenatide on the expression of C-peptide and on the clinical outcome in the treatment of type 2 diabetes.       Methods      A total of 78 hospitalized patients with type 2 diabetes in our department from January 2012 to June 2013 were prospectively recruited, and then divided into 2 groups, the control group and the treatment group. The treatment group had 39 patients, including 16 males and 23 females, at an average age of 49.0±6.0, and received metformin combined with exenatide. Whereas, there were 39 patients in the control group, including 21 males and 18 females, with the average age of 50.1±5.9 and being given metformin combined with Gansulin. All these patients were treated for 16 weeks. The indicates, including fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), fasting C-peptide, 2-hour postprandial C-peptide, and BMI were compared between 2 groups before and after treatment.       Results        At 16 weeks after the treatment, the fasting and 2-h postprandial C-peptide levels were increased in the treatment group (P<0.05), but the control group had no obvious change in the 2 indicators (P>0.05). FBG, 2hPG and HbA1c were significantly decreased in the both 2 groups (P<0.05), but there was no statistical difference between them (P>0.05). The body weight, circumference of abdomen, and BMI of all the patients were decreased, and the decrease was more significantly in the treatment group than in the control group (P<0.05).       Conclusion       Exenatide combined with metformin effectively improves the C-peptide level, and reduces blood glucose, HbA1c, body weight, circumference of abdomen and BMI in the patients with type 2 diabetes.

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更新日期/Last Update: 2014-07-25