[1]张鑫,田跃,童卫东,等.直肠内脱垂患者直肠顺应性变化与肠黏膜中TRPV1、5-HT表达的关系[J].陆军军医大学学报(原第三军医大学学报),2013,35(21):2282-2285.
 Zhang Xin,Tian Yue,Tong Weidong,et al.Relationship of TRPV1/5-HT expression in intestinal mucosa and rectal compliance in patients with internal rectal prolapse[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(21):2282-2285.
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
35卷
期数:
2013年第21期
页码:
2282-2285
栏目:
论著
出版日期:
2013-11-15

文章信息/Info

Title:
Relationship of TRPV1/5-HT expression in intestinal mucosa and rectal compliance in patients with internal rectal prolapse
作者:
张鑫田跃童卫东李凡王李赵松叶景旺刘宝华
第三军医大学大坪医院野战外科研究所普通外科,全军便秘诊治中心
Author(s):
Zhang Xin Tian Yue Tong Weidong Li Fan Wang Li Zhao Song Ye Jingwang Liu Baohua

Department of General Surgery, Center of Constipation Diagnosis and Treatment, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China

关键词:
肛管直肠测压TRPV15-HT直肠内脱垂
Keywords:
anorectal manometry transient receptor potential vanilloid 1 5-hydroxytryptamine internal rectal prolapse
分类号:
R392.3; R446.8; R574.63
文献标志码:
A
摘要:

目的      探讨直肠内脱垂(internal rectal prolapse,IRP)患者直肠顺应性改变与TRPV1、5-HT在直肠黏膜层表达的关系。      方法        选择临床诊断IRP的患者20例及对照组20例先进行肛管直肠测压,然后行结肠镜检查,在齿状线上方4 cm处下段直肠取黏膜活检,行TRPV1和5-HT免疫组化染色,采用图像分析法分析免疫反应阳性情况。      结果       与对照组比较,IRP组初始感觉容积明显增高(Z=-3.710,P<0.01),最大感觉耐受容积明显降低(Z=-5.181,P<0.01),直肠顺应性明显降低;对照组黏膜层仅有少量TRPV1表达,IRP组直肠黏膜腺体可见大量TRPV1阳性染色,与对照组相比,IRP组直肠黏膜层TRPV1的表达显著增强(Z=-5.085, P<0.01);对照组黏膜层5-HT免疫阳性染色很少,而IRP组黏膜层腺体细胞内5-HT表达量显著升高(Z=-4.734, P<0.01)。      结论        IRP患者直肠顺应性明显低于对照组,与直肠黏膜层TRPV1和5-HT免疫反应阳性显著增强导致直肠高敏感有关,可能是IRP患者肛门坠胀、便意频繁等排便功能障碍的机制之一。

Abstract:

Objective        To investigated the relationship of expression changes of transient receptor potential vanilloid 1 (TRPV1) and 5-hydroxytryptamine (5-HT) in rectal mucosa and rectal compliance in the patients with internal rectal prolapse (IRP).       Methods        A total of 20 out-patients who were diagnosed as IRP in our department and 20 sex- and age-matched healthy individuals for physical examination from October to December 2012 were enrolled in this study. They received colonoscopy after anorectal manometry. Immunohistochemical assay for TRPV1 and 5-HT was carried out in the mucosal samples from the lower rectum at 4 cm above the dentate line.       Results        The initial sensation volume was significantly higher in IRP group than in normal control (Z=-3.710,P<0.01), but the largest feeling tolerance volume was obviously lower in IRP group (Z=-5.181, P<0.01). The rectal compliance was significantly lower in the IRP group than in normal control.TRPV1 was extensively expressed in the rectal mucosa of IRPs when compared in that of control (Z=-5.085, P<0.01). Similar expression was found in 5-HT in the rectal mucosa (Z=-4.734, P<0.01).       Conclusion        Rectal compliance in patients with IRP is significantly lower than normal control, which might be related with the significantly enhanced expression of TRPV1 and 5-HT in rectal mucosa which causes rectal hypersensitivity. It is may be one of the mechanisms of bowel dysfunction as anal bulge and frequent defecation in patients with internal rectal prolapse.

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更新日期/Last Update: 2013-11-06