[1]罗刚,刁鑫伟,李长青,等.新型动态加压交锁髓内针对骨折愈合的影响[J].陆军军医大学学报(原第三军医大学学报),2012,34(19):1989-1993.
　Luo Gang,Diao Xinwei,Li Changqing,et al.Effect of novel dynamic compressive interlocking intramedullary nail on fracture healing[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(19):1989-1993.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第19期
页码:
1989-1993
栏目:
论著
出版日期:
2012-10-15

文章信息/Info

Title:
Effect of novel dynamic compressive interlocking intramedullary nail on fracture healing
作者:
罗刚; 刁鑫伟; 李长青; 周跃
第三军医大学新桥医院：骨科，病理科
Author(s):
Luo Gang;  Diao Xinwei;  Li Changqing;  Zhou Yue
Department of Orthopedics, Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
关键词:
交锁髓内针; 骨折愈合; 动态压应力; Ⅰ型胶原; 骨钙素
Keywords:
interlocking intramedullary nail;  fracture healing;  dynamic stress;  type Ⅰ collagen;  osteocalcin
分类号:
R-332; R683.05; R687.33
文献标志码:
A
摘要:
目的      探讨新型动态加压交锁髓内针影响骨折愈合的组织学及骨痂内Ⅰ型胶原和骨钙素的表达变化。      方法      2周岁青山羊15只，制作双侧股骨干中段横断骨折模型，实验侧以新型动态加压交锁髓内针固定，旨在骨折断端形成持续性动态压应力条件，对照侧以普通髓内针固定。于术后第7、14、30、60、90天在骨折愈合处取材，行组织病理学和RT-PCR等检测。      结果      组织学检测示实验组骨折间隙内软骨痂基质的钙化、软骨内成骨及编织骨的改建均快于对照组。RT-PCR检测示2组Ⅰ型胶原和骨钙素表达均在骨折术后上升，分别于术后14、30 d时相点达到峰值，实验组明显高于对照组（P<0.05）。      结论      新型动态加压交锁髓内针能够促进成骨细胞外基质的合成、分泌和软骨内成骨，从而有效加速骨折愈合过程。
Abstract:
Objective       To study the effect of novel dynamic compressive interlocking intramedullary nail on histology of fracture healing and expression of type Ⅰ collagen and osteocalcin in callus.       Methods        Fifteen 2-years-old goats were included in this study. A bilateral middle femoral shaft transverse fracture model was established. Its experimental side was internally fixed with dynamic compressive intramedullary nails to produce continuous dynamic compressive stress and its opposite side was fixed with ordinary intramedullary nails. Samples were taken from the healed fracture on days 7, 14, 30, 60 and 90, respectively, after operation. The fracture healing was assessed by histopathology and RT-PCR, respectively.       Results        Histology examination showed that the calcification of cartilage matrix in the fracture space and the reconstruction of osteogenesis and woven bone within the cartilage were faster in the experimental side than in the opposite side. RT-PCR displayed that the expression levels of type Ⅰ collagen and osteocalcin were higher after operation than before operation, reached their peak on days 14 and 30 after operation respectively, and were significantly higher in experimental group than in control group (P<0.05).       Conclusion        Novel dynamic compression intramedullary nail can effectively accelerate the healing of fractures by stimulating the bone extracellular matrix synthesis, secretion and formation of endochondrostosis.

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更新日期/Last Update: 2012-09-27