[1]罗刚,刁鑫伟,李长青,等.新型动态加压交锁髓内针对骨折愈合的影响[J].陆军军医大学学报(原第三军医大学学报),2012,34(19):1989-1993.
 Luo Gang,Diao Xinwei,Li Changqing,et al.Effect of novel dynamic compressive interlocking intramedullary nail on fracture healing[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(19):1989-1993.
点击复制

新型动态加压交锁髓内针对骨折愈合的影响(/HTML )
分享到:

陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第19期
页码:
1989-1993
栏目:
论著
出版日期:
2012-10-15

文章信息/Info

Title:
Effect of novel dynamic compressive interlocking intramedullary nail on fracture healing
作者:
罗刚刁鑫伟李长青周跃
第三军医大学新桥医院:骨科,病理科
Author(s):
Luo Gang Diao Xinwei Li Changqing Zhou Yue
Department of Orthopedics, Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
关键词:
交锁髓内针骨折愈合动态压应力Ⅰ型胶原骨钙素
Keywords:
interlocking intramedullary nail fracture healing dynamic stress type Ⅰ collagen osteocalcin
分类号:
R-332; R683.05; R687.33
文献标志码:
A
摘要:
目的      探讨新型动态加压交锁髓内针影响骨折愈合的组织学及骨痂内Ⅰ型胶原和骨钙素的表达变化。      方法      2周岁青山羊15只,制作双侧股骨干中段横断骨折模型,实验侧以新型动态加压交锁髓内针固定,旨在骨折断端形成持续性动态压应力条件,对照侧以普通髓内针固定。于术后第7、14、30、60、90天在骨折愈合处取材,行组织病理学和RT-PCR等检测。      结果      组织学检测示实验组骨折间隙内软骨痂基质的钙化、软骨内成骨及编织骨的改建均快于对照组。RT-PCR检测示2组Ⅰ型胶原和骨钙素表达均在骨折术后上升,分别于术后14、30 d时相点达到峰值,实验组明显高于对照组(P<0.05)。      结论      新型动态加压交锁髓内针能够促进成骨细胞外基质的合成、分泌和软骨内成骨,从而有效加速骨折愈合过程。
Abstract:
Objective       To study the effect of novel dynamic compressive interlocking intramedullary nail on histology of fracture healing and expression of type Ⅰ collagen and osteocalcin in callus.       Methods        Fifteen 2-years-old goats were included in this study. A bilateral middle femoral shaft transverse fracture model was established. Its experimental side was internally fixed with dynamic compressive intramedullary nails to produce continuous dynamic compressive stress and its opposite side was fixed with ordinary intramedullary nails. Samples were taken from the healed fracture on days 7, 14, 30, 60 and 90, respectively, after operation. The fracture healing was assessed by histopathology and RT-PCR, respectively.       Results        Histology examination showed that the calcification of cartilage matrix in the fracture space and the reconstruction of osteogenesis and woven bone within the cartilage were faster in the experimental side than in the opposite side. RT-PCR displayed that the expression levels of type Ⅰ collagen and osteocalcin were higher after operation than before operation, reached their peak on days 14 and 30 after operation respectively, and were significantly higher in experimental group than in control group (P<0.05).       Conclusion        Novel dynamic compression intramedullary nail can effectively accelerate the healing of fractures by stimulating the bone extracellular matrix synthesis, secretion and formation of endochondrostosis.

相似文献/References:

[1]温轩,谢杨丽,苏楠,等.小鼠胫骨稳定性骨折模型制作及评价[J].陆军军医大学学报(原第三军医大学学报),2013,35(05):404.
 Wen Xuan,Xie Yangli,Su Nan,et al.Preparation and evaluation of mouse model of stable tibial fracture[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(19):404.
[2]何海涛,谭颖徽,王建华,等.SP在失神经下颌骨骨痂中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2005,27(15):1558.
[3]谢杨丽,苏楠,金旻,等.外源性甲状旁腺素对小鼠骨折愈合的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1003.
 Xie Yangli,Su Nan,Jin Min,et al.Effects of exogenous PTH1-34 on healing of bone fracture in mice[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(19):1003.
[4]李曙光,张国志,袁强,等.妊娠对兔骨折愈合的影响研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(22):2420.
 Li Shuguang,Zhang Guozhi,Yuan Qiang,et al.Effect of pregnancy on fracture healing in rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(19):2420.
[5]张俊山,田发明,康玉川,等.高生物涂层局部应用辛伐他汀对大鼠骨质疏松性骨折愈合的影响[J].陆军军医大学学报(原第三军医大学学报),2013,35(12):1274.
 Zhang Junshan,Tian Faming,Kang Yuchuan,et al.Effect of local application of simvastatin in biodegradable coating of osteosynthetic implants on osteoporotic fracture healing in rats[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(19):1274.
[6]初同伟,王正国,朱佩芳,等.VEGF在骨折愈合过程中对Ⅷ因子相关抗原表达变化影响的实验研究[J].陆军军医大学学报(原第三军医大学学报),2002,24(02):0.[doi:10.16016/j.1000-5404.2002.02.006 ]
 CHU Tong wei,WANG Zheng guo,ZHU Pei fang.[J].J Amry Med Univ (J Third Mil Med Univ),2002,24(19):0.[doi:10.16016/j.1000-5404.2002.02.006 ]
[7]吴雪晖,李起鸿.锥状点式接触钢板与传统钢板对骨折愈合影响的对比实验研究[J].陆军军医大学学报(原第三军医大学学报),2000,22(08):0.[doi:10.16016/j.1000-5404.2000.08.012 ]
 WU Xue hui,LI Qi hong.[J].J Amry Med Univ (J Third Mil Med Univ),2000,22(19):0.[doi:10.16016/j.1000-5404.2000.08.012 ]
[8]卢卫忠,唐康来,杨柳,等.不同时间给予转化生长因子β对兔骨折愈合作用的研究[J].陆军军医大学学报(原第三军医大学学报),2003,25(09):0.[doi:10.16016/j.1000-5404.2003.09.004 ]
 LU Wei zhong,TANG Kang lai,YANG Liu,et al.[J].J Amry Med Univ (J Third Mil Med Univ),2003,25(19):0.[doi:10.16016/j.1000-5404.2003.09.004 ]
[9]卢卫忠,唐康来,朱庆和,等.不同剂量转化生长因子β对兔尺骨骨折愈合作用的研究[J].陆军军医大学学报(原第三军医大学学报),2003,25(11):0.[doi:10.16016/j.1000-5404.2003.11.019 ]
 LU Wei zhong,TANG Kang lai,ZHU Qing he,et al.[J].J Amry Med Univ (J Third Mil Med Univ),2003,25(19):0.[doi:10.16016/j.1000-5404.2003.11.019 ]
[10]陈卫刚,钟朝林,马川,等.可吸收防粘连膜防治股中间肌粘连的疗效[J].陆军军医大学学报(原第三军医大学学报),2003,25(20):0.[doi:10.16016/j.1000-5404.2003.20.020 ]

更新日期/Last Update: 2012-09-27