[1]朱进,安洪伟,赵涌,等.钙视网膜蛋白在先天性巨结肠病理诊断中的应用[J].陆军军医大学学报(原第三军医大学学报),2012,34(19):2005-2008.
　Zhu Jin,An Hongwei,Zhao Yong,et al.Application of calretinin in pathological diagnosis of Hirschsprung disease[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(19):2005-2008.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第19期
页码:
2005-2008
栏目:
论著
出版日期:
2012-10-15

文章信息/Info

Title:
Application of calretinin in pathological diagnosis of Hirschsprung disease
作者:
朱进; 安洪伟; 赵涌; 李昱
重庆医科大学基础医学院：病理学教研室，神经科学中心，重庆市神经生物学重点实验室
Author(s):
Zhu Jin;  An Hongwei;  Zhao Yong;  Li Yu
Department of Pathology, Neuroscience Center, Chongqing Key Laboratory of Neurobiology, College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China
关键词:
先天性巨结肠; 钙视网膜蛋白; 胆碱酯酶染色
Keywords:
Hirschsprung disease;  calretinin;  acetylcholinesterase staining
分类号:
R341; R446.8; R574.62
文献标志码:
A
摘要:
目的      研究钙视网膜蛋白（calretinin，CR）免疫组织化学染色及胆碱酯酶染色（acetylcholinesterase staining，AchE ）在先天性巨结肠（hirschsprung disease，HD）病理诊断中的作用对比，并探讨在直肠黏膜活检标本不足时CR的诊断作用。       方法      采用回顾性研究的方法对比163例直肠黏膜活检CR免疫组织化学染色与AchE染色诊断HD准确性及敏感性。研究26例只含有1个黏膜下神经丛的直肠黏膜活检标本中，CR免疫组织化学染色辅助病理诊断的准确率。       结果      在年龄<3个月的病例组中，CR免疫组织化学染色敏感度显著高于AchE染色。CR免疫组织化学染色能够准确诊断21例只含有1个黏膜下神经丛的直肠黏膜活检HD病例。       结论      CR免疫组织化学染色是一种优于AchE染色的直肠黏膜活检诊断HD的必要辅助方法。
Abstract:
Objective      To study the role of calretinin (CR) immunohistochemical and acetylcholinesterase (AchE) staining in pathological diagnosis of Hirschsprung disease (HD) and the role of CR immunohistochemical staining in pathological diagnosis of HD when the rectum mucosal biopsy samples were inadequate.       Methods      The accuracy and sensitivity of CR immunohistochemical staining of rectum mucosal biopsy samples from 163 HD patients were retrospectively studied and compared. The accuracy of CR immunohistochemical staining of rectum mucosal biopsy samples containing 1 submucosal nerve plexus was studied in pathological diagnosis of HD in 26 patients.       Results      The sensitivity of CR immunohistochemical staining was significantly higher than AchE staining for the diagnosis of HD in patients aged <3 months. The CR immunohistochemical staining of rectum mucosal biopsy samples containing 1 submucosal nerve plexus could accurately diagnose HD in 21 patients.       Conclusion      CR immunohistochemical staining of rectum mucosal biopsy samples is better than AchE staining of rectum mucosal biopsy samples in diagnosis of HD.

相似文献/References:

[1]刘占奎,张超,余佩武,等.成人先天性巨结肠1例[J].陆军军医大学学报(原第三军医大学学报),2003,25(18):0.[doi:10.16016/j.1000-5404.2003.18.036 ]
[2]朱进,金先庆.Bcl-2、钙视网膜蛋白在发育异常肠壁神经节细胞中的表达[J].陆军军医大学学报(原第三军医大学学报),2010,32(01):60.
　Zhu Jin,Jin Xianqing.Expression of Bcl-2 and calretinin in dysplasia enteric ganglion cells of hirschsprung patients[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(19):60.

更新日期/Last Update: 2012-09-27