[1]尹清,树海峰,刘宏亮,等.血清和脑脊液中IL-6含量变化在儿童难治性癫痫发作中的意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(12):1234-1236.
 Yin Qing,Shu Haifeng,Liu Hongliang,et al.Significance of interleukin-6 levels in serum and cerebrospinal fluid for pediatric intractable epilepsy[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(12):1234-1236.
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血清和脑脊液中IL-6含量变化在儿童难治性癫痫发作中的意义(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第12期
页码:
1234-1236
栏目:
论著
出版日期:
2012-06-30

文章信息/Info

Title:
Significance of interleukin-6 levels in serum and cerebrospinal fluid for pediatric intractable epilepsy
作者:
尹清树海峰刘宏亮杨辉
第三军医大学西南医院康复科;第三军医大学新桥医院神经外科,全军癫痫病诊治中心
Author(s):
Yin Qing Shu Haifeng Liu Hongliang Yang Hui
Department of Rehabilitation, Southwest Hospital, Third Military Medical University, Chongqing,400038;Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing,400037, China
关键词:
小儿难治性癫痫癫痫发作白细胞介素-6
Keywords:
pediatric intractable epilepsy seizure IL-6
分类号:
R392.32;R446.1;R749.17
文献标志码:
A
摘要:
目的      探讨白细胞介素-6 (IL-6)与小儿难治性癫痫发病机制之间的潜在关系。      方法      采用酶联免疫吸附法检测48例小儿难治性癫痫患者癫痫发作后血清和脑脊液中IL-6的含量变化。      结果      癫痫发作1、6 h后,癫痫组患者血清IL-6水平分别为(8.23±0.58)、(11.63±1.35)pg/ml,与正常对照组(0.75±0.48)pg/ml相比有统计学意义(P<0.05,P<0.01);癫痫发作1、6 h后,脑脊液中IL-6水平亦逐渐升高,分别为(10.35±3.06)、(19.55±2.32)pg/ml,显著高于正常对照组[(1.27±0.65) pg/ml,P<0.01];而发作后12 h,癫痫组患者血清和脑脊液中的IL-6含量趋于正常[分别为(1.05±0.66)、(3.54±1.31)pg/ml],与正常对照组相比无显著差异(P>0.05)。      结论      癫痫发作可诱导血清和脑脊液中IL-6表达水平的上调,这可能促进炎性损伤的进一步加重,可能与小儿难治性癫痫的病情进展密切相关。
Abstract:
Objective      To explore the potential relationship between the level of IL-6 in the serum and cerebrospinal fluid (CSF) and epileptogenesis of pediatric intractable epilepsy.       Methods      Using the ELISA method to detect the changes of IL-6 content in 48 cases of pediatric intractable epilepsy seizures in the serum and cerebrospinal fluid.       Results      The IL-6 level in serum was 8.23±0.58 pg/ml and 11.63±1.35 pg/ml in 1 h and 6 h after seizure, respectively, which was significantly different with controls (0.75±0.48 pg/ml,1 h: P<0.05; 6 h: P<0.01) . In addition, The IL-6 level in serum was 10.35±3.06 pg/ml and 19.55±2.32 pg/ml in 1 h and 6 h after seizure, respectively, which was also significantly increased compared with controls (1.27±0.65 pg/ml,P<0.01). However, the IL-6 levels in serum and CSF 12 h after seizure were tendency towards the baseline.       Conclusion      The seizure induced an increase of IL-6 levels in serum and CSF, which may exacerbate the injury caused by inflammation, would be involved in the epileptogenesis of pediatric intractable epilepsy.

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更新日期/Last Update: 2012-06-15