[1]刘波涛,王凯,许雪青,等.Bax基因P53结合位点多态性与食管鳞癌易感性的关联研究[J].第三军医大学学报,2012,34(10):963-966.
 Liu Botao,Wang Kai,Xu Xueqing,et al.Association between SNP in P53-binding site of Bax and risk of esophageal squamous cell carcinoma in southwest Chinese Han population[J].J Third Mil Med Univ,2012,34(10):963-966.
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Bax基因P53结合位点多态性与食管鳞癌易感性的关联研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第10期
页码:
963-966
栏目:
论著
出版日期:
2012-05-30

文章信息/Info

Title:
Association between SNP in P53-binding site of Bax and risk of esophageal squamous cell carcinoma in southwest Chinese Han population
作者:
刘波涛王凯许雪青熊刚郭洪官兴颖白云
第三军医大学:基础医学部医学遗传学教研室,西南医院胸心外科
Author(s):
Liu Botao Wang Kai Xu Xueqing Xiong Gang Guo Hong Guan Xingying Bai Yun
Department of Medical Genetics, College of Basic Medical Science, Department of Cardiothoracic Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China
关键词:
BaxP53单核苷酸多态性(SNP)食管鳞状细胞癌危险因素
Keywords:
Bax P53 single nucleotide polymorphism (SNP) esophageal squamous cell carcinoma risk factor
分类号:
R394.5;R730.23;R735.1
文献标志码:
A
摘要:
目的      探讨Bax基因P53结合位点多态性与我国西南地区食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)发病的关联性。      方法      利用SNaPshot技术检测201例食管鳞癌病例组及183例健康对照的Bax基因rs1009316位点多态性的分布情况,分析不同基因型与食管鳞癌易感性的关联。      结果      食管鳞癌病例组和对照组中rs1009316 的CC和CT/TT基因型频率分别为 59.2%、40.8%和73.2%、26.8%,CT/TT相比CC增加食管鳞癌的发病风险(OR值为1.884,95%CI为1.224~2.901),T等位基因增加食管鳞癌的发病风险(OR值1.620,95%CI为1.103~2.379)。分层分析发现,无吸烟史群体中,T等位基因(OR值为1.858,95%CI为1.050~3.288)及CT/TT基因型(OR值为2.178,95%CI为1.143~4.147)分别增加食管鳞癌的发病风险。      结论      在中国西南地区人群中,Bax基因P53结合区域的多态性位点rs1009316是食管鳞癌的危险因素之一。
Abstract:
Objective      To evaluate the association between single nucleotide polymorphism (SNP) in P53-binding site of Bax and the risk of esophageal squamous cell carcinoma (ESCC) in southwest Chinese Han population.       Methods      The SNaPshot technique was applied to detect genotype of rs1009316  in 201 cases of ESCC (ESCC group) and 183 cases of healthy controls (control group), and the association between different genotypes of rs1009316 and the risk of ESCC was analyzed.       Results      The frequencies of the rs1009316 variants CC and CT/TT were 59.2% and 40.8% in the ESCC group and 73.2% and 26.8% in the control group, respectively. Compared with CC genotype, CT/TT genotype increased the risk of ESCC (OR 1.884, 95% CI 1.224 to 2.901). T allele frequency was 20% in the ESCC group and 14% in the control group, and T allele was positively correlated with the risk of ESCC (OR 1.620, 95% CI 1.103 to 2.379). In stratification analysis, CT/TT genotype and T allele increased the risk of ESCC in the subjects without smoking history.       Conclusion      rs1009316 a SNP lying in the p53-binding site of Bax, is a risk factor of ECSS in southwest Chinese Han population.

参考文献/References:

刘波涛, 王凯, 许雪青, 等. Bax基因P53结合位点多态性与食管鳞癌易感性的关联研究[J].第三军医大学学报,2012,34(10):963-966.

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更新日期/Last Update: 2012-05-21