[1]田小利,秦波.趋化因子与干扰素治疗慢性乙肝病毒学应答的相关性[J].陆军军医大学学报(原第三军医大学学报),2012,34(16):1668-1671.
 Tian Xiaoli,Qin Bo.Relationship between chemokine levels and virological response to PegIFNα-2a treatment in patients with chronic hepatitis B[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(16):1668-1671.
点击复制

趋化因子与干扰素治疗慢性乙肝病毒学应答的相关性(/HTML )
分享到:

陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第16期
页码:
1668-1671
栏目:
论著
出版日期:
2012-08-30

文章信息/Info

Title:
Relationship between chemokine levels and virological response to PegIFNα-2a treatment in patients with chronic hepatitis B
作者:
田小利秦波
重庆医科大学附属第一医院感染科
Author(s):
Tian Xiaoli Qin Bo
Department of Infectious Diseases, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China
关键词:
慢性病毒性肝炎乙型聚乙二醇干扰素趋化因子
Keywords:
chronic hepatitis B PEGylated interferon alpha chemokines
分类号:
R512.62;R969;R977
文献标志码:
A
摘要:
目的      探讨血清趋化因子水平和慢性乙型病毒性肝炎患者聚乙二醇干扰素治疗病毒学应答之间的相关性。      方法      纳入基因型为B型的慢性乙肝患者36例,于首次干扰素治疗前采血,检测血清CXCL9、CXCL10、CCL3、CCL5浓度。患者均接受聚乙二醇干扰素α-2a 180 μg 每周1次治疗,随访治疗3、6个月的疗效。      结果      二元Logistic回归分析发现,仅治疗前血清CXCL9及AST是早期病毒学应答的独立预测指标。将患者分为血清CXCL9≥39.51 ng/L和血清CXCL9<39.51 ng/L 2组。治疗3个月时,两组的早期病毒学应答率分别为78.95%(15/19)和23.53%(4/17),两组间差异有显著性(P<0.05);治疗6个月时,维持应答率在两组分别为63.16%(12/19)和11.76%(2/17),两组间差异有显著性(P<0.05)。      结论      CXCL9表达水平较高的患者经聚乙二醇干扰素治疗后病毒学应答率较高,可能有利于指导慢性乙型肝炎患者的个体化用药。
Abstract:
Objective      To elucidate the possible association between serum chemokine levels and virological response to PEGylated interferon (PegIFN) α-2a treatment in patients with chronic hepatitis B.        Methods      Thirty-six patients infected with genotype B hepatitis B virus (HBV) were recruited in this study. The serum levels of CXCL9, CXCL10, CCL3 and CCL5 were measured by ELISA before treatment. All the patients were treated with PegIFNα-2a 180 μg every week and then followed up for 6 months.        Results      The results of binary logistic regression analysis found that the serum levels of CXCL9 and aspartate aminotransferase (AST) before treatment were the independent predictors for early virological response. The patients were then divided into two groups including a high CXCL9 group (serum level of CXCL9≥39.51 ng/L) and a low CXCL9 group (serum level of CXCL9<39.51 ng/L). After the treatment for 3 months, the rates of early virological response were 78.95% (15/19) in the high CXCL9 group and 23.53% (4/17) in the low CXCL9 group, respectively (P<0.05). After the treatment for 6 months, the rates of maintained virological response were 63.16% (12/19) in the high CXCL9 group and 11.76% (2/17) in the low CXCL9 group, respectively (P<0.05).       Conclusion      Patients with a high level of CXCL9 have a high rate of virological response to PegIFNα-2a treatment, which may help to improve the efficacy of PegIFNα-2a treatment for patients with chronic hepatitis B.

相似文献/References:

[1]田沂,唐晓鹏,杨旭,等.HBV标志物定量与病毒载量关系探讨[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1305.
 TIAN Yi,TANG Xiao-peng,YANG Xu,et al.Correlation of virus load to contents of serologic markers in HBV patients[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(16):1305.
[2]万涛,张小花,张磊,等.HBV对肝癌细胞中AKR1C1基因表达的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(03):297.
[3]张长江,熊瑜琳,谭朝霞,等.阿德福韦联合恩替卡韦治疗多药物作用后慢性乙型肝炎的早期疗效评估及其影响因素分析[J].陆军军医大学学报(原第三军医大学学报),2010,32(22):2413.
 Zhang Changjiang,Xiong Yulin,Tan Zhaoxia,et al.Early response to adefovir and entecavir combination in chronic hepatitis B patients after multi-antivirus drugs sequential therapy and influencing factors[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(16):2413.
[4]李丹,丁健,林纳,等.乙型肝炎病毒PreS1蛋白与初期多肽相关复合体α亚单位特异性结合的研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(23):2315.
 LI Dan,DING Jian,LIN Na,et al.Interaction between hepatitis B virus PreS1 protein and nascent-polypeptide-associated complex alpha polypeptide[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(16):2315.
[5]黄亚琴,杨丽莎,吴淋玲.HBV基因型在HBV感染性肝癌及慢性HBV感染自然史不同阶段的分布[J].陆军军医大学学报(原第三军医大学学报),2011,33(12):1258.
 Huang Yaqin,Yang Lisha,Wu Linling.Distribution of HBV genotypes in HBV infection-associated hepatocellular carcinoma and in different phases of natural chronic HBV infection history[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(16):1258.
[6]唐玉兰,谭文婷,谭顺,等.282例散发性戊型肝炎流行病学及临床特征分析[J].陆军军医大学学报(原第三军医大学学报),2011,33(11):1178.
 Tang Yulan,Tan Wenting,Tan Shun,et al.Epidemiological and clinical characteristics of sporadic hepatitis E: A report of 282 cases[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(16):1178.
[7]谭文婷,邓国宏,王宇明,等.重庆地区乙肝病毒基因型分布及其临床意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(24):2321.
 TAN Wen-ting,DENG Guo-hong,WANG Yu-ming,et al.HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(16):2321.
[8]刘明,邓国宏,谭顺,等.慢加急性肝衰竭前期临床常规预警指标研究[J].陆军军医大学学报(原第三军医大学学报),2012,34(08):772.
 Liu Ming,Deng Guohong,Tan Shun,et al.Routine early clinical warning indicators of acute-on-chronic pre-liver failure[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(16):772.
[9]周泓羽,杜渝平,袁喆.替比夫定对乙型肝炎病毒母婴阻断效果的Meta分析[J].陆军军医大学学报(原第三军医大学学报),2013,35(20):2220.
 Zhou Hongyu,Du Yuping,Yuan Zhe.Efficacy of telbivudine on preventing mother-to-child transmission of hepatitis B virus: a Meta-analysis[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(16):2220.
[10]罗晓丽,谭文婷,周媛,等.ERα及ERβ在HBV相关肝细胞癌中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2014,36(06):564.
 Luo Xiaoli,Tan Wenting,Zhou Yuan,et al.Expression of estrogen receptors α and β in hepatitis B virus-related hepatocellular carcinoma and clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2014,36(16):564.

更新日期/Last Update: 2012-07-30