[1]张娟,陈旻静,王大伟,等.组织蛋白酶D和基质金属蛋白酶-9在皮肤恶性黑色素瘤中的表达[J].陆军军医大学学报(原第三军医大学学报),2012,34(10):1002-1005.
 Zhang Juan,Chen Minjing,Wang Dawei,et al.Expression of Cath-D and MMP-9 in cutaneous malignant melanoma[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(10):1002-1005.
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组织蛋白酶D和基质金属蛋白酶-9在皮肤恶性黑色素瘤中的表达(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第10期
页码:
1002-1005
栏目:
论著
出版日期:
2012-05-30

文章信息/Info

Title:
Expression of Cath-D and MMP-9 in cutaneous malignant melanoma
作者:
张娟陈旻静王大伟刘林嶓王喜梅郭丽丽王琰
郑州大学第一附属医院整形外科
Author(s):
Zhang Juan Chen Minjing Wang Dawei Liu Linbo Wang Ximei Guo Lili Wang Yan
Department of Plastic Surgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, 450052, China
关键词:
皮肤恶性黑色素瘤组织蛋白酶D基质金属蛋白酶-9浸润转移
Keywords:
cutaneous malignant melanoma Cath-D MMP-9 infiltration metastasis
分类号:
R345;R446.6;R739.5
文献标志码:
A
摘要:
目的      检测 Cath-D和MMP-9和在皮肤恶性黑色素瘤、交界痣及正常皮肤中表达情况,及其与皮肤恶性黑色素瘤的临床分期,淋巴结转移的关系。      方法      应用免疫组化S-P法对分别检测Cath-D和MMP-9在44例皮肤恶性黑色素瘤、22例皮肤交界痣及20例正常皮肤中的表达水平。      结果      Cath-D和MMP-9在皮肤恶性黑色素瘤中的阳性表达率(79.55%和75.00%)均高于交界痣(45.45%和40.91%)及正常皮肤组织(15.00%和30.00%)(P<0.05),Cath-D和MMP-9在皮肤恶性黑色素瘤中的阳性表达率随肿瘤浸润深度的增加而增高,且有淋巴结转移者阳性表达率大于无淋巴结转移者(P<0.05)。皮肤恶性黑色素瘤中Cath-D和MMP-9的表达呈正相关(rs=0.488, P<0.05)。      结论      Cath-D和MMP-9在皮肤恶性黑色素瘤的发生、发展中可能起着重要作用,且与CMM的浸润转移密切相关,且二者之间可能具有协同作用。联合检测两者的表达情况可为CMM的早期诊断及预后提供新的靶点。
Abstract:
Objective      To investigate the expression of cathepsin D (cath-D) and matrix metalloproteinase 9 (MMP-9) in cutaneous malignant melanoma (CMM), junctional nevus and normal skin, and its relationship with the clinical stages and lymph node metastasis of CMM.       Methods      The expression of Cath-D and MMP-9 was detected in 44 cases of CMM, 22 cases of junctional nevus and 20 cases of normal skin specimens by SP immunohistochemical method.       Results      The positive expression rates of Cath-D and MMP-9 in the CMM (79.55% and 75.00%) were higher than those in the junctional nevus (45.45% and 40.91%) and normal skin (15.00% and 30.00%) (P<0.05). The positive expression rates of Cath-D and MMP-9 in the CMM increased along with the increase in the depth of tumor invasion, and higher positive expression rates of Cath-D and MMP-9 were detected in the CMM patients with lymph node metastasis than in those without lymph node metastasis. There was a positive correlation between Cath-D and MMP-9 expression in the CMM tissues (rs=0.488, P<0.05).       Conclusion      Cath-D and MMP-9 are important in the tumorigenesis and development of CMM and are closely related to CMM invasion and metastasis, with a possible synergistic effect. Combined detection of Cath-D and MMP-9 expression may help both early diagnosis and prognosis of CMM.

相似文献/References:

[1]肖华亮,王东,李增鹏,等.骨肉瘤组织蛋白酶D表达及其与预后的关系[J].陆军军医大学学报(原第三军医大学学报),1999,21(02):0.[doi:10.16016/j.1000-5404.1999.02.014 ]
 Xiao Hualiang,Wang Dong,Li Zengpeng,et al.[J].J Amry Med Univ (J Third Mil Med Univ),1999,21(10):0.[doi:10.16016/j.1000-5404.1999.02.014 ]

更新日期/Last Update: 2012-05-21