[1]李莹,宋耀明,赵友光,等.急性冠脉综合征患者血清APN、HO-1水平与冠状动脉病变严重程度的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2011,33(08):845-848.
　Li Ying,Song Yaoming,Zhao Youguang,et al.Correlation study on serum adiponectin and heme oxygenase-1 levels and severity of coronary artery disease in patients with acute coronary syndrome[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(08):845-848.
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急性冠脉综合征患者血清APN、HO-1水平与冠状动脉病变严重程度的相关性研究(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第08期
页码:
845-848
栏目:
论著
出版日期:
2011-04-30

文章信息/Info

Title:
Correlation study on serum adiponectin and heme oxygenase-1 levels and severity of coronary artery disease in patients with acute coronary syndrome
作者:
李莹; 宋耀明; 赵友光; 任可; 李燕; 卢巍
第三军医大学新桥医院心血管内科，全军心血管病研究所；成都军区总医院泌尿外科
Author(s):
Li Ying;  Song Yaoming;  Zhao Youguang;  Ren Ke;  Li Yan;  Lu Wei
Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, Department of Urology, General Hospital of Chengdu Military Command, Chengdu,Sichuan Province, 610083, China
关键词:
急性冠脉综合征; APN; HO-1; 冠状动脉病变
Keywords:
acute coronary syndrome;  APN;  HO-1;  coronary artery disease
分类号:
R181.32；R541.4；R446.1
文献标志码:
A
摘要:
目的    通过测定急性冠脉综合征（acute coronary syndrome，ACS）患者血清脂联素 (adiponectin，APN)及血红素加氧酶-1 (heme oxygenase-1，HO-1)水平,分析其与冠状动脉病变程度的相关性，探讨二者在冠心病中的相互作用。    方法    入选160例行冠状动脉造影（CAG）患者,根据患者病史及CAG结果分为2组：急性冠脉综合征（ACS）组92例，稳定型心绞痛（SAP）组68例；50例对照组为非冠心病CAG阴性组。用Gensini评分系统对冠脉病变程度评分。根据Gensini评分系统对冠脉病变组分为Gensini积分≥30分组和＜30分组，再根据冠脉病变支数分为单只、双支和3支病变组。采双抗体夹心ELISA法测定ACS组、SAP组、正常对照组血清APN、HO-1水平。分别比较其二者之间的相关性及与冠脉病变的严重程度（Gensini积分）的相关性。    结果    ACS组和SAP组血清APN及HO-1水平均明显低于对照组[(5.84±2.29)、(8.01±2.04) vs (15.27±2.51)mg/L；(24.08±7.88)、(32.86±10.97) vs (54.35±14.8)μg/L, P<0.01]。按冠状动脉病变支数分组,冠状动脉病变支数多者血清APN、HO-1水平较冠状动脉病变支数少者亦显著降低。Gensini积分≥30分APN、HO-1水平[ (5.75±2.28)mg/L、（22.27±6.5）μg/L]明显低于＜30分组[(7.55±2.29)mg/L、（32.38±10.6）μg/L， P<0.01]。APN与HO-1呈正相关(r=0.598， P<0.01)，Gensini积分与血清APN、HO-1水平均呈负相关(r=-0.576， P<0.01； r=-0.456， P<0.01)。    结论    血清APN与HO-1密切相关，且与冠状动脉病变严重程度密切相关，且二者之间可能存在相互调节。
Abstract:
Objective    To study the correlation between the levels of serum adiponectin (APN) and heme oxygenase-1 (HO-1) and the severity of coronary artery disease in the patients with acute coronary syndrome (ACS), and investigate the interaction between APN and HO-1 in coronary heart disease.     Methods    One-hundred-and-sixty patients who had positive results in coronary angiography (CAG) were divided in an ACS group (n=92) and a stable angina pectoris (SAP) group (n=68) according to their medical histories and CAG results. In addition, fifty normal subjects who had negative results in CAG were involved as a control group. The patients were also divided in a one-branch group, a two-branch group, and a three-branch group according to the number of affected coronary branches, and in a ≥30 score group and a <30 score group based on the Gensini scoring system. The serum APN and HO-1 levels were measured by double-antibody sandwich ELISA in all the subjects. The correlation between the serum APN level and the serum HO-1 level, and that between the levels of serum APN and HO-1 and the severity of coronary artery disease were determined by comparison.     Results    The levels of serum APN and HO-1 were significantly lower in the ACS group and the SAP group than in the control group (5.84±2.29 and 8.01±2.04 vs 15.27±2.51 mg/L; 24.08±7.88 and  32.86±10.97 vs 54.35±14.8 μg/L). The larger the number of affected coronary branches, the lower the levels of serum APN and HO-1 (4.71±1.42 and 7.37±1.81 vs 9.23±1.76 mg/L; 20.17±6.53 and 29.35±5.72 vs 38.40±10.41 μg/L). The levels of serum APN and HO-1 were significantly lower in the ≥30 score group than in the <30 score group (5.75±2.28 vs 7.55±2.29 mg/L; 22.27±6.50 vs 32.38±10.60 μg/L). The serum APN level was positively correlated with the serum HO-1 level (r=0.598, P<0.01). The Gensini score was negatively correlated with the levels of serum APN and HO-1 (r=-0.576, P<0.01; r=-0.456, P<0.01).     Conclusion    The serum APN level is intimately and positively correlated with the serum HO-1 level. The levels of serum APN and HO-1 are negatively correlated with the severity of coronary artery disease. APN and HO-1 may interact in the development of coronary heart disease.

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更新日期/Last Update: 2011-04-13