[1]李慎柯,柴玉荣,张春霞,等.肿瘤相关抗原p62应用于肿瘤免疫诊断的Meta 分析[J].陆军军医大学学报(原第三军医大学学报),2011,33(03):270-273.
 Li Shenke,Chai Yurong,Zhang Chunxia,et al.Application of tumor-associated antigen p62 in immunodiagnosis of carcinoma: A Meta-analysis[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(03):270-273.
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第03期
页码:
270-273
栏目:
论著
出版日期:
2011-02-15

文章信息/Info

Title:
Application of tumor-associated antigen p62 in immunodiagnosis of carcinoma: A Meta-analysis
作者:
李慎柯柴玉荣张春霞鲁照明王凯娟代丽萍张建营
河南省濮阳市油田总医院肿瘤科;郑州大学:基础医学院组织学与胚胎学教研室,河南省肿瘤流行病学重点实验室
Author(s):
Li ShenkeChai YurongZhang ChunxiaLu ZhaomingWang Kaijuan Dai Liping Zhang Jianying
Department of Oncology, General Hospital of Puyang Oil Field, Puyang, Henan Province, 457001; Department of Histology and Embryology, College of Basic Medicine, Zhengzhou University, Henan Province, Zhengzhou, 450001;Henan Provincial Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, Henan Province, 450001, China
关键词:
Meta分析肿瘤相关抗原p62肿瘤诊断
Keywords:
Meta-analysis tumor-associated antigen p62 immunologic test
分类号:
R195.1; R341; R730.4
文献标志码:
A
摘要:
目的   分析肿瘤相关抗原p62在免疫诊断中的作用和价值。   方法     采用Cochrane系统评价方法,通过计算机检索中国学术期刊全文数据库、万方数据库、维普咨询网、中国生物医学文献数据库和PubMed、Springer、Elsevier、EBSCO 外文数据库,并辅以手工检索,检索时间截止至2010年6月。获取p62用于肿瘤血清学免疫诊断的病例-对照研究共18篇文献,采用Cochrane协作网Review Manager 4.2.8软件进行Meta分析。   结果     以p62能否应用于肿瘤的免疫诊断为题,共纳入17项研究,包括6种不同的肿瘤类型,含1554例肿瘤患者病例和1461例正常人对照,目的均是检测p62自身抗体在肿瘤患者和正常对照中出现的例数。统计得出总的效应统计量比值比(odds ratio,OR)及其95%CI为10.74(7.25~15.90),差异具有统计学意义(P<0.01)。   结论   Meta分析结果表明肿瘤患者血清中抗p62自身抗体的检测在免疫诊断中具有实际应用价值。
Abstract:
Objective    To analyze the role of tumor-associated antigen p62 in immunodiagnosis of cancer.    Methods    Eighteen papers on case-control studies were searched from CNKI Full-text Database, China Medical Academic Conference Database, Wanfang Database, VIP Information Database, PubMed, Springer, Elsevier, and EBSCO plus manual search of related journals in Library of Zhengzhou University (till June 2010). A Meta-analysis of the data was performed using the Cochrane review manager software 4.2.8 (RevMan 4.2.8).    Results    The eligible 17 studies on the immunodiagnosis of cancer involving 6 different cancers with p62 included 1 554 cancer patients and 1 461 normal controls . Meta-analysis showed that the total odds ratio (OR) and 95% confidence interval (95%CI) were 10.74 (7.25 to 15.90, P<0.01).    Conclusion    Detection of anti-p62 in sera of tumor patients is of practical value in immunodiagnosis of carcinoma.

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更新日期/Last Update: 2011-01-31