[1]张红,赵聪敏.孕早期暴露家装空气污染物及高温对新生鼠神经行为的影响[J].第三军医大学学报,2009,31(22):2181-2185.
 ZHANG Hong,ZHAO Cong-min.Effects of early pregnancy exposure to hazardous indoor air pollutants due to interior decoration and hyperthermia on neurobehavioral development of postnatal rats[J].J Third Mil Med Univ,2009,31(22):2181-2185.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第22期
页码:
2181-2185
栏目:
专题报道
出版日期:
2009-11-30

文章信息/Info

Title:
Effects of early pregnancy exposure to hazardous indoor air pollutants due to interior decoration and hyperthermia on neurobehavioral development of postnatal rats
作者:
张红赵聪敏
第三军医大学新桥医院儿科
Author(s):
ZHANG Hong ZHAO Cong-min
Department of Pediatrics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
污染物高温孕鼠神经行为
Keywords:
indoor pollutants hyperthermia pregnant rats neurobehavior
分类号:
R122;R715.3;R748
文献标志码:
A
摘要:
目的  探讨孕早期暴露家装空气污染物以及联合高温对新生大鼠神经行为的影响。  方法  22只孕鼠随机分为4组,每天置于污染物柜、高温柜、高温联合污染物柜以及空染毒柜中2 h时,共10 d,然后对其分娩的新生鼠在不同时间点观察体质量变化和神经行为学改变。同时观察大鼠海马CA1区凋亡和死亡神经元的数量并检测海马组织中NMDA受体NR1亚基的基因表达变化。  结果  化学污染物、高温可导致新生鼠海马神经元的死亡和凋亡以及促进海马NMDA受体NR1基因的表达,并对其神经行为、学习记忆能力有显著的影响,二者联合可加重其损伤作用。  结论  孕早期暴露家装空气污染物和高温环境会对新生鼠神经系统的发育产生明显影响。
Abstract:
Objective   To investigate the effects of early pregnancy exposure to hazardous indoor air pollutants due to interior decoration and hyperthermia on neurobehavioral development of postnatal rats.    Methods   Twenty-two pregnant rats were randomly divided into 4 groups. Each group was placed in pollutants cabinet, hyperthermia cabinet, hyperthermia+pollutants cabinet and empty cabinet respectively for 2 h per day for 10 d since their pregnancy. The weight and neurobehavioral development of postnatal rats were observed at different time points. The number of apoptotic and dead neurons in the CA1 region of hippocampus was observed in postnatal rats. The expression of the NR1 subunit of NMDA receptor of hippocampal neurons was also detected.    Results   Indoor pollutants and hyperthermia could accelerate apoptosis and necrosis of hippocampal neurons in CA1 region of postnatal rats and increase the expression of NR1 subunit of NMDA receptor. Furthermore, hazardous indoor pollutants and hyperthermia could induce remarkable influences on postnatal rats’ neurobehavioral development, learning and memory capability. Indoor pollutants combined with hyperthermia aggravated these effects.    Conclusion   Exposure to environment of the hazardous indoor pollutants especially combined with hyperthermia during early pregnancy has remarkable influences on the nervous system of postnatal rats. 

参考文献/References:

张红,赵聪敏.孕早期暴露家装空气污染物及高温对新生鼠神经行为的影响[J]. 第三军医大学学报,2009,31(22):2181-2185.

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更新日期/Last Update: 2009-11-23