[1]金卫东,王自立,马小民,等.156例脊柱结核患者抗结核药物副作用临床分析[J].第三军医大学学报,2009,31(20):1932-1935.
 JIN Wei-dong,WANG Zi-li,MA Xiao-min,et al.Side effects of anti-tuberculosis drugs in 156 spinal tuberculosis patients[J].J Third Mil Med Univ,2009,31(20):1932-1935.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第20期
页码:
1932-1935
栏目:
专题报道
出版日期:
2009-10-30

文章信息/Info

Title:
Side effects of anti-tuberculosis drugs in 156 spinal tuberculosis patients
作者:
金卫东王自立马小民刘斌朱涛
宁夏医科大学:附属医院脊柱外科,宁夏医科大学临床学院
Author(s):
JIN Wei-dong WANG Zi-li MA Xiao-min LIU Bin ZHU Tao
Department of Spinal Surgery, Affiliated Hospital of Ningxia Medical University,Clinic College of Ningxia Medical University, Yinchuan 750004, China
关键词:
脊柱抗结核药物副作用
Keywords:
spine anti-tuberculosis drugs side effects
分类号:
R529.205;R969;R978.3
文献标志码:
A
摘要:
目的   阐明脊柱结核抗结核药物副作用发生情况及预防、处理措施。   方法   对1998年1月至2007 年12月间经我院确诊治疗的脊柱结核患者156 例进行临床回顾性研究。   结果   发生抗结核药物副作用68 例(43.6 %)114例次,以肝功能损害、位听神经损害、胃肠反应及视力损害为主(86.0%),因副作用致终止治疗4例,占2.6%。其中发生1种同类别副作用43例,2种副作用20例,3种以上副作用5例。抗结核药物的副作用多出现于用药早期,2个月内占67.5%。   结论   抗结核药物引起的副作用较常见,临床常易忽视,若发生抗结核药物严重副作用,易引起严重后果,应引起临床医生高度重视。
Abstract:
Objective   To elucidate the occurrence, prevention and treatment of the side effects  caused by anti-tuberculosis drugs for spinal tuberculosis.    Methods   Between January 1998 and December 2007, 156 hospitalized patients with spinal tuberculosis were reviewed.    Results   There were 68 cases (43.6%) of the patients suffered side effects caused by anti-tuberculosis drugs (114 times). The symptoms of liver functional lesion, acoustic nerve injury, gastrointestinal response and eyesight injury of them were primary (86.0%). There were 4 cases (about 2.6%) having to stop anti-tuberculosis treatment due to side effects. In this group there were 43 cases having one kind of side-effects, 20 cases having two kinds of side effects, and 5 cases having three or more side effect. There were 67.5% having side effects occurred within 2 months after administration.    Conclusion   The side effects of anti-tuberculosis drugs are common, but often ignored by patients. If patients have serious side effects of anti-tuberculosis drugs, it will easily lead to serious consequences, so clinicians should pay more attention to it.

参考文献/References:

金卫东, 王自立, 马小民, 等. 156例脊柱结核患者抗结核药物副作用临床分析[J]. 第三军医大学学报,2009,31(20):1932-1935.

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更新日期/Last Update: 2009-10-21