[1]程悦,张静波,李芙蓉,等.系膜增生性肾小球肾炎患者血清Th1/Th2细胞因子表达的变化[J].陆军军医大学学报(原第三军医大学学报),2009,31(09):860-862.
　CHENG Yue,ZHANG Jing-bo,LI Fu-rong,et al.Expression of Th1/Th2 cytokines in patients with mesangial proliferative nephritis[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(09):860-862.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
31卷
期数:
2009年第09期
页码:
860-862
栏目:
论著
出版日期:
2009-05-15

文章信息/Info

Title:
Expression of Th1/Th2 cytokines in patients with mesangial proliferative nephritis
作者:
程悦; 张静波; 李芙蓉; 王代红; 袁发焕
第三军医大学新桥医院肾内科,全军肾脏病中心,重庆市肾脏病研究所
Author(s):
CHENG Yue;  ZHANG Jing-bo;  LI Fu-rong;  WANG Dai-hong;  YUAN Fa-huan
Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
系膜增生性肾小球肾炎; INF-γ; IL-4; IL-10
Keywords:
mesangial proliferative nephritis;  INF-γ; IL-4; IL-10
分类号:
R392.11;R392.32;R692.31
文献标志码:
A
摘要:
目的   观察系膜增生性肾小球肾炎患者血清Th1和Th2类细胞因子（INF-γ、IL-4、IL-10）表达变化。   方法   采用酶联免疫吸附实验（ELISA）测定10例正常人和25例慢性肾小球疾病患者（轻中度系膜增生性非IgA肾小球肾炎）外周静脉血血清INF-γ、IL-4、IL-10细胞因子水平。   结果   系膜增生性肾小球肾炎患者血清INF-γ分泌水平较正常人明显增多（P<0.01），而IL-10分泌水平较正常人明显减少（P<0.05），IL-4分泌水平则与正常人无显著差异（P>0.05），系膜增生性肾小球肾炎患者INF-γ/IL-4、INF-γ/IL-10值均显著高于正常人（P<0.05）。   结论   系膜增生性肾小球肾炎患者在外周血细胞因子水平存在Th1/Th2免疫失衡，可能参与了系膜增生性肾小球肾炎的免疫发病机制。
Abstract:
Objective   To investigate the expressions of Th1 and Th2 cytokines including INF-γ, IL-4 and IL-10 in patients with mesangial proliferative nephritis (MsPGN).    Methods   Twenty-five patients with pathologically diagnosed MsPGN (mild or moderate proliferation) who admitted in our hospital from November 2007 to May 2008 were enrolled in this study. Another 10 healthy individuals served as normal control. Their clinical parameters including ALT, creatine, albumin, WBC and C3 were compared. ELISA was used to determine their serum levels of INF-γ, IL-4 and IL-10.    Results   The C3 level was significantly lower in MsPGN group than in normal control, but there was no significant difference in other clinical parameters. Serum level of IFN-γ was higher in MsPGN patients than that in normal control (P<0.01), and IL-10 levels in MsPGN patients were lower than that in healthy individuals (P<0.05). There was no significant difference in IL-4 contents between MsPGN patients and normal control (P>0.05). The INF-γ/IL-4 ratio and INF-γ/IL-10 ratio in MsPGN patients were significantly higher than those in healthy donors (P<0.01).    Conclusion   The polarization of Th1 cytokines in MsPGN patients indicates that Th1 cytokines may be involved in the pathogenesis of MsPGN.

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更新日期/Last Update: 2009-04-27