[1]谭文婷,邓国宏,王宇明,等.重庆地区乙肝病毒基因型分布及其临床意义[J].第三军医大学学报,2008,30(24):2321-2323.
 TAN Wen-ting,DENG Guo-hong,WANG Yu-ming,et al.HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population[J].J Third Mil Med Univ,2008,30(24):2321-2323.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第24期
页码:
2321-2323
栏目:
论著
出版日期:
2008-12-30

文章信息/Info

Title:
HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population
作者:
谭文婷邓国宏王宇明但芸婕况雪梅
第三军医大学西南医院全军感染病研究所
Author(s):
TAN Wen-ting DENG Guo-hong WANG Yu-ming DAN Yun-jie KUANG Xue-mei
Institution of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
关键词:
肝炎病毒乙型基因型疾病表型HBV DNA
Keywords:
hepatitis virus type B genotype disease phenotype HBV DNA
分类号:
R181.33;R373.21;R512.620.1
文献标志码:
A
摘要:
目的    调研重庆地区乙型肝炎病毒(hepatitis B virus, HBV)基因型构成,探讨HBV基因型与乙型肝炎疾病进程的相关性。    方法    用SSP-PCR法对360例HBV DNA阳性患者HBV基因分型,采用多因素Logistic回归分析HBV基因型与疾病表型的相关性。    结果    本回顾性研究人群中,HBV-B型占45.6%,HBV-C型占53.9%,分型失败0.5%。随着疾病从慢性乙型肝炎到肝硬化、原发性肝细胞癌的进展,C型HBV所占比例显著上升(χ2=23.368,P<0.001)。Logistic回归分析显示HBV基因型是HBV感染者罹患肝癌的独立风险因素(OR=3.2, P=0.01)。B、C基因型患者的HBV DNA水平和HBeAg阳性率无显著差异(P>0.05)。      结论    重庆地区HBV基因型以B、C型为主,C型HBV更易导致严重的肝病,HBV基因型是影响疾病进程的重要因素。
Abstract:
Objective    To study the distribution of hepatitis B virus (HBV) genotypes in Chongqing city and its clinical influences.      Methods    The genotype of HBV was detected by SSP-PCR while the HBV DNA by FQ-PCR and HBeAg by ELISA.      Results    Among 360 HBV DNA positive patients who have lived in Chongqing, the prevalence of HBV/B and C was 45.6% and 53.9%, respectively. The rate of genotype C increased with the progression of chronic liver disease from chronic hepatitis B (CHB) (42.4%), liver cirrhosis (LC) (67.4%) to hepatocellular carcinoma (HCC) (74.0%), with significant differences among these groups (χ2=23.368, P<0.01). Logistic regression analysis indicated that HBV genotype is an independent risk factor for HBV-related HCC (OR=3.2, P=0.01). No significant difference was found in the positive rate of HBeAg or the serum level of HBV DNA among the patients of genotype B and C (P>0.05), even though the positive rate of HBeAg was slightly higher in the patients of genotype B (40.9%) than that of genotype C (36.1%).     Conclusion    Genotype C and B are the dominant genotypes for Chongqing population. The damage to liver induced by genotype C is more severe than that by genotype B. HBV genotype plays a role in the progression of serious HBV-related liver disease.

参考文献/References:

谭文婷, 邓国宏, 王宇明, 等. 重庆地区乙肝病毒基因型分布及其临床意义[J].  第三军医大学学报, 2008, 30(24):2321-2323.

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更新日期/Last Update: 2008-11-12