[1]王明军,宋青,张宏,等.异丙酚对猕猴再灌注肺损伤的保护作用机制[J].陆军军医大学学报(原第三军医大学学报),2008,30(17):1591-1593.
 WANG Ming-jun,SONG Qing,ZHANG Hong,et al.Propofol protects Rhesus macaques from reperfusion lung injury[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(17):1591-1593.
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第17期
页码:
1591-1593
栏目:
论著
出版日期:
2008-09-15

文章信息/Info

Title:
Propofol protects Rhesus macaques from reperfusion lung injury
作者:
王明军宋青张宏米卫东
解放军总医院: 麻醉手术中心,  外科重症监护科
Author(s):
WANG Ming-jun SONG Qing ZHANG Hong MI Wei-dong
Department of Anesthesiology, General Surgery ICU, General Hospital of PLA, Beijing 100853, China
关键词:
异丙酚休克出血性肺损伤病理生理学
Keywords:
propofol shock hemorrhagic lung injury pathology
分类号:
R563; R969; R971.2
文献标志码:
A
摘要:
目的    通过观察异丙酚在猕猴失血性休克并复苏过程中对病理生理学变化的作用,探讨休克复苏引起肺损伤的原因和异丙酚的保护作用机制。    方法    12只猕猴按随机数字表法分为对照组和异丙酚组,每组6只。建立失血性休克复苏导致再灌注肺损伤的动物模型。异丙酚组猕猴除在放血前用计算机靶控技术输注异丙酚使猴血浆异丙酚浓度达到8 mg/L并维持此水平到实验结束外,其余操作与对照组相同。分别于放血前、休克2 h和复苏2 h测定血流动力学参数,并抽动脉血行血气分析、血常规检验。    结果    异丙酚组在休克2 h和复苏2 h时平均肺动脉压(MPA)、肺血管阻力指数(PVRI)均明显低于对照组(P<0.05),血小板(PLT)计数明显高于对照组(P<0.01);复苏2 h时异丙酚组白细胞(WBC)计数明显低于对照组(P<0.01)。    结论    休克复苏时肺动脉高压和全身炎性反应可能是导致肺损伤的原因,异丙酚可通过降低肺动脉压和减轻全身炎性反应显著减轻肺损伤。
Abstract:
Objective    To find out the cause of lung injury due to hemorrhagic shock and resuscitation, and the mechanism of propofol protecting Rhesus macaques from lung injury.     Methods    Twelve healthy Rhesus macaques were randomly divided into two groups: propofol group and control group. The animal model was made by 2-hour hemorrhagic shock and 2-hour resuscitation. Rhesus macaques in propofol group were given propofol at a plasma concentration of 8 mg/L all through by the technique of target controlled infusion. Hemodynamic parameters, gas analysis and RBC, WBC, HB and PLT contents from collected arterial blood were respectively determined before bleeding, 2 h after hemorrhagic shock and 2 h after resuscitation.     Results    Mean pulmonary arterial pressure and pulmonary vascular resistance index in propofol group 2 h after hemorrhagic shock and 2 h after resuscitation were significantly lower than those in control group (P<0.05), while the platelet count in propofol group was higher than that in control group (P<0.01). WBC count in propofol group 2 h after resuscitation was significantly less than that in control group (P<0.01).     Conclusion    Pulmonary hypertension and systemic inflammatory response may cause lung injury in Rhesus macaques during shock and resuscitation. Propofol can remarkably relieve the lung injury by ameliorating pulmonary circulation and alleviating systemic inflammatory response.

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更新日期/Last Update: 2008-09-16