[1]王军,房殿春,赵晶京,等.Claudin 3在食管腺癌和贲门腺癌的表达和意义[J].第三军医大学学报,2008,30(10):932-934.
 WANG Jun,FANG Dian-chun,ZHAO Jing-jing,et al.Expression and significance of Claudin 3 in adenocarcinoma of esophagus and cardia adenocarcinoma[J].J Third Mil Med Univ,2008,30(10):932-934.
点击复制

Claudin 3在食管腺癌和贲门腺癌的表达和意义(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第10期
页码:
932-934
栏目:
论著
出版日期:
2008-05-30

文章信息/Info

Title:
Expression and significance of Claudin 3 in adenocarcinoma of esophagus and cardia adenocarcinoma
作者:
王军房殿春赵晶京杨仕明
第三军医大学西南医院全军消化病研究所
Author(s):
WANG Jun FANG Dian-chun ZHAO Jing-jing YANG Shi-ming
Gastroenterology Research Center, Southwest Hospital, Third Military Medical University
关键词:
Claudin 3食管腺癌贲门腺癌
Keywords:
Claudin 3 esophagus adenocarcinoma cardia adenocarcinoma
分类号:
R730.23;R735.1;R735.2
文献标志码:
A
摘要:
目的  探讨Claudin 3在食管腺癌和贲门腺癌的表达及意义。  方法  分别采用RT-PCR及Western blot检测16例食管腺癌、20例食管鳞癌、15例弥漫型贲门腺癌、25例肠型贲门腺癌、15例正常食管黏膜和15例正常贲门黏膜组织中Claudin 3 mRNA及蛋白表达。  结果  与正常对照组和食管鳞癌、贲门弥漫型腺癌组相比,食管腺癌和贲门肠化型腺癌组织中Claudin 3 mRNA及蛋白表达显著增高(P<0.01);食管鳞癌组、贲门弥漫型癌组Claudin 3 mRNA及蛋白表达与正常对照组无明显变化(P>0.05)。  结论  Claudin 3与食管腺癌和贲门肠化型腺癌发生有关。
Abstract:
Objective  To investigate the expression and significance of Claudin 3 in adenocarcinoma of esophagus and gastric cardia.   Methods  We subjected pathologically confirmed 16 cases of esophageal adenocarcinoma (EAC), 20 cases of esophageal squamous cell carcinoma (ESC), and 40 cases of gastric cardiac adenocarcinoma (CAC, including 15 diffuse and 25 intestinal cases). Tissue samples were collected with aid of gastroscope. Fifteen samples of normal esophageal mucosa and 15 samples of normal cardiac mucosa served as control. RT-PCR and Western blotting were used respectively to detect the mRNA and protein expression of Claudin 3 in these tissue samples.   Results  The mRNA and protein expressions of Claudin 3 were increased in EAC and intestinal CA compared with those in normal tissues, ESC and diffuse CAC. There was no significant difference of the expression of Claudin 3 between normal group and ESC and diffuse CAC group.   Conclusion  Claudin 3 might be related to the development of EAC and intestinal CAC, and expected to be the tumor maker and therapeutic target of this kind of carcinoma.
更新日期/Last Update: 2008-05-26