[1]朱超慧,陈东风,艾正琳,等.非酒精性脂肪性肝病的临床、病理与CT的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(17):1665-1667.
　ZHU Chao-hui,CHEN Dong-feng,AI Zheng-lin,et al.Relationships among pathological changes, clinical features and CT manifestation of nonalcoholic fatty liver disease[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(17):1665-1667.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第17期
页码:
1665-1667
栏目:
论著
出版日期:
2008-09-15

文章信息/Info

Title:
Relationships among pathological changes, clinical features and CT manifestation of nonalcoholic fatty liver disease
作者:
朱超慧; 陈东风; 艾正琳; 史洪涛; 杨丽; 钟西琳
第三军医大学大坪医院野战外科研究所消化内科
Author(s):
ZHU Chao-hui;  CHEN Dong-feng;  AI Zheng-lin;  SHI Hong-tao;  YANG Li;  ZHONG Xi-lin
Department of Gastroenterology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
关键词:
非酒精性脂肪性肝病; 病理; CT检查
Keywords:
nonalcoholic fatty liver disease;  pathology;  CT
分类号:
R361; R575.5; R814.42
文献标志码:
A
摘要:
目的    研究非酒精性脂肪性肝病(nonalcoholic fatty liver disease，NAFLD)的病理变化、临床特征与肝脏CT影像学改变的关系。    方法    对45例患者的肝组织标本按脂肪变、炎症和纤维化程度分级、分期，并研究其与腰围、臀围、腰臀比、体质量指数、血清生化指标的关系,其中16例行肝脏CT，分别测定肝脏及脾脏不同断面的平均CT值，并对肝组织脂肪变程度进行分析。    结果    45例患者按肝组织脂肪变分级：12例为F0(设为对照组)，19例为F1，13例为F2，1例为F3；肝组织炎症活动度分级：9例为G0，14例为G1，17例为G2，5例为G3；肝组织纤维化分级：11例为S0，9例为S1，16例为S2，5例为S3。肝组织脂肪变程度与腰围(r=0.357，P=0.028)、腰臀比(r=0.463，P=0.001 6)、总胆固醇（TC）(r=0.484，P=0.004)呈显著正相关。其中16例病例行肝脏CT检查，肝组织脂肪变与肝脏CT值呈显著负相关(r=－0.592，P=0.016)，F0、F1、F2各组之间肝脾比值无显著差异(P>0.05)。    结论    随着腰围、腰臀比、TC的增高，NAFLD患者肝组织脂肪变程度逐渐加重；转氨酶高低并不与肝组织脂肪变程度相平行；随着肝细胞脂肪变程度的加重，肝脏CT值逐渐减低，但肝脾比值不能准确反映脂肪肝程度的差异。
Abstract:
Objective    To study the pathological changes, clinical features and CT manifestation of nonalcoholic fatty liver disease (NAFLD)．    Methods    The relationships among histopathologic features of the liver, serum biochemical parameters and other clinical data of 45 NAFLD patients were studied. CT examinations were performed in 16 patients.     Results    According to liver fatty degeneration grading, 12 cases were classified to F0, 19 cases to F1, 13 cases to F2 and 1 case to F3. As to the grading of inflammatory activities, 9 cases were G0, 14 G1, 17 G2 and 5 G3. As to the grading of fibrosis, 11 cases were S0, 9 S1, 16 S2 and 5 S3. The hepatocyte steatosis was correlated to waistline (r=0.357, P=0.028), waist-to-hip ratio (r=0.463, P=0.001 6), and total cholesterol (r=0.484, P=0.004). The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) showed no significant difference among each grade of liver inflammatory activity. The grade of hepatic steatosis was negatively correlated with liver value of CT. The liver-to-spleen ratios were not significantly different among F0, F1 and F2.     Conclusion    In NAFLD patients, with the increment of waistline, waist-to-hip ratio and TC, the steatosis gets worse. The levels of ALT and AST do not parallel with the hepatic steatosis. The degree of steatosis is negatively correlated with the liver value of CT, but the liver-to-spleen ratio does not reflect the grade of the liver degeneration.

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更新日期/Last Update: 2008-09-17