[1]何小峰,王继成,辛建兰.血浆置换治疗慢性重型肝炎60例临床分析[J].陆军军医大学学报(原第三军医大学学报),2007,29(23):2289-2291.
 HE Xiao-feng,WANG Ji-cheng,XIN Jian-lan.Retrospective analysis of plasma exchange for chronic severe hepatitis[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(23):2289-2291.
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第23期
页码:
2289-2291
栏目:
论著
出版日期:
2007-12-15

文章信息/Info

Title:
Retrospective analysis of plasma exchange for chronic severe hepatitis
作者:
何小峰王继成辛建兰
扬州大学医学院附属泰兴市人民医院感染科
Author(s):
HE Xiao-feng WANG Ji-cheng XIN Jian-lan
Department of Infectious Diseases, The Affiliated Taixing People’s Hospital of Medical College of Yangzhou University
关键词:
血浆置换重型肝炎疗效预后
Keywords:
plasma exchange severe hepatitis efficacy prognosis
分类号:
R457; R512.605
文献标志码:
A
摘要:
目的  回顾分析慢性重型肝炎患者行血浆置换术(plasma exchange, PE)的疗效及其影响因素。  方法  应用血浆置换联合内科综合治疗60例慢性重型肝炎患者,分析总结患者的治疗效果和影响疗效的有关因素。  结果  60例慢性重型肝炎患者经血浆置换治疗后有效率为61.7%。PE的疗效与患者年龄、临床分期、PE治疗前血清胆红素值及凝血酶原活动度(PTA)、并发症的发生率有密切关系(P<0.01)。PE的疗效与治疗次数无明显关系(P>0.05)。  结论  行血浆置换术可明显提高慢性重型肝炎患者的存活率,尤其是对于年龄在60岁以下、血清总胆红素(TBIL)水平较低、PTA值较高、临床处于早中期的患者。改善重型肝炎的预后仍需针对患者病情特点早期治疗,积极防治并发症。
Abstract:
Objective  To retrospectively analyse the efficacy and the influencing factors of plasma exchange (PE) in patients with chronic severe hepatitis.   Methods  Sixty patients of chronic severe hepatitis were included.   Results  The effective rate was 61.7%. The efficacy of PE was closely related to age, clinical stage, pre-treatment serum bilirubin values, prothrombin activity and incidence of complications (P<0.01). No significant correlation was observed between the efficacy and the treatment frequency of PE (P>0.05).   Conclusion  PE can significantly improve the survival of patients with chronic severe hepatitis. Especially for the patients under 60 years old, those with low serum TBIL level and high PTA, and those in the early clinical stage, PE treatment would achieve a better efficacy. But the improvement of prognosis of severe hepatitis still depends on the early specific treatment and active prevention of complications.

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更新日期/Last Update: 2008-05-23