[1]侯君,周世文.甘草酸固体脂质纳米粒的处方及制备工艺[J].第三军医大学学报,2008,30(11):1043-1045.
 HOU Jun,ZHOU Shi-wen.Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles[J].J Third Mil Med Univ,2008,30(11):1043-1045.
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甘草酸固体脂质纳米粒的处方及制备工艺(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第11期
页码:
1043-1045
栏目:
论著
出版日期:
2008-06-15

文章信息/Info

Title:
Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles
作者:
侯君周世文
第三军医大学新桥医院临床药理基地
Author(s):
HOU Jun ZHOU Shi-wen
State Base for Clinical Pharmacology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
甘草酸固体脂质纳米粒正交设计包封率载药量
Keywords:
glycyrrhizic acid solid lipid nanoparticle orthogonal design encapsulation drug loading
分类号:
R282.71; R943; R944.9
文献标志码:
A
摘要:
目的  制备甘草酸固体脂质纳米粒(GL-SLN)。  方法  用旋转蒸发薄膜超声法制备GL-SLN,在单因素考察的基础上,通过正交设计优选该纳米粒的处方及制备工艺,并对优化条件下制备的GL-SLN进行质量评价。   结果  制备的GL-SLN大小较均匀,平均粒径为75.8 nm,zeta电位-19.7 mV,载药量8.27%,包封率91.76%。 结论 薄膜超声分散法优化工艺制备得到的GL-SLN包封率较高,稳定性好,方法可靠。
Abstract:
Objective    To prepare the glycyrrhizic acid solid lipid nanoparticles (GL-SLN).     Methods    GL-SLN was prepared by conventional rotary-evaporated film-ultrasonication method. Based on the single-factor experiment, GL-SLN was prepared using orthogonal design for optimization of formulation and technology. The obtained GL-SLN was also evaluated.     Results    GL-SLN had even and regular appearance and the average diameter was 75.8 nm. Zeta potential was -19.7 mV. The drug loading was 8.27% and the entrapment ratio was 91.76%.     Conclusion    The entrapment ratio of GL-SLN and the stability of GL-SLN prepared by conventional rotary-evaporated film-ultrasonication method are high and good.

参考文献/References:

侯君,周世文. 甘草酸固体脂质纳米粒的处方及制备工艺[J].第三军医大学学报,2008,30(11):1043-1045.

相似文献/References:

[1]李开龙,贾昆霞,张建国,等.甘草酸对实验性梗阻性肾病大鼠的保护作用[J].第三军医大学学报,2001,23(05):0.[doi:10.16016/j.1000-5404.2001.05.040 ]
 LI Kai long,JIA Kun xia,ZHANG Jian guo,et al.[J].J Third Mil Med Univ,2001,23(11):0.[doi:10.16016/j.1000-5404.2001.05.040 ]

更新日期/Last Update: 2008-06-06