[1]李涛,方玉强,刘良明,等.羟乙基淀粉对失血性休克大鼠复苏效果的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(14):1319-1321.
 LI Tao,FANG Yu-qiang,LIU Liang-ming,et al.Effects of hydroxyethyl starch at different molecular weights on hemorrhagic shock in rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):1319-1321.
点击复制

羟乙基淀粉对失血性休克大鼠复苏效果的影响(/HTML )
分享到:

陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
30卷
期数:
2008年第14期
页码:
1319-1321
栏目:
论著
出版日期:
2008-07-30

文章信息/Info

Title:
Effects of hydroxyethyl starch at different molecular weights on hemorrhagic shock in rats
作者:
李涛方玉强刘良明杨成民
天津协和生物科技发展研究所;第三军医大学大坪医院野战外科研究所第二研究室,创伤、烧伤与复合伤国家重点实验室
Author(s):
LI Tao FANG Yu-qiang LIU Liang-ming YANG Cheng-min
Tianjin Concord Biotech Development Research Institute, Tianjin 310045; State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
关键词:
失血性休克羟乙基淀粉万汶贺斯
Keywords:
hemorrhagic shock hydroxyethyl starch Voluven Haes
分类号:
R457;R605.971;R977.6
文献标志码:
A
摘要:
目的  比较不同相对分子质量的6%羟乙基淀粉(hydroxyethyl starch, HES)/0.9% NaCl溶液对大鼠失血性休克的复苏效果。 方法  SD大鼠制作45%放血失血性休克模型,观察相对分子质量为40、130、200的HES40、HES130、HES200对休克动物平均动脉血压(mean arterial blood pressure, MAP)、血流动力学和血气指标的影响,同时观察存活时间和24 h存活率,并以万汶和贺斯作为对照组。 结果  自制不同相对分子质量HES可以改善MAP、左心室收缩压(left intraventricular systolic pressure, LVSP)、左心室压力上升或下降的最大速率(maximal change rate of left intraventricular pressure, ±dp/dtmax)等血流动力学指标,效果与血气贺斯组相当,HES130和HES200组动物存活时间略高于HES40,其中以HES200效果最好,与万汶和贺斯效果相当。 结论  3种不同相对分子质量的HES均具有明显抗失血性休克作用,其中以HES200效果更明显。
Abstract:
Objective    To compare the resuscitation effect of 6% hydroxyethyl starch (HES) of different molecular weight in normal saline on hemorrhagic shock in rats.     Methods    Hemorrhagic shock model was established in 50 SD rats by 45% hemorrhage, and then they were equally divided into 5 groups. The rats were administered  with HES40/, HES130/, HES200/normal saline, Voluven or Haes. Their mean arterial blood pressure (MAP), left intraventricular systolic pressure (LVSP), the maximal change rate of left intraventricular pressure (±dp/dtmax) of hemorrhagic shock rat were observed. Meanwhile, the artery blood gas, the survival time and 24-hour survival rate were also observed.     Results    Similar hemodynamic parameters values were obtained in the rats treated with our HES and those with Voluven or Haes. HES130 and HES200 prolonged the survival time of shocked animals in comparison with HES40. Among the 3 types of HES, HES200 had the best effect, which is equivalent to Voluven and Haes.     Conclusion    HES of 3 molecular weights have beneficial effect on hemorrhagic shock, and HES200 exerts best.

相似文献/References:

[1]方玉强,李涛,刘良明.精氨酸血管加压素抗失血性休克作用及其与Rho kinase的关系[J].陆军军医大学学报(原第三军医大学学报),2008,30(13):1223.
 FANG Yu-qiang,LI Tao,LIU Liang-ming.Antishock effect of arginine vasopressin and its relationship with Rho kinase[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):1223.
[2]朱乐明,董兆君.失血性休克复合氰化钠中毒对兔血清氧化应激水平的影响[J].陆军军医大学学报(原第三军医大学学报),2006,28(05):428.
[3]徐竞,杨光明,李涛,等.缺血预适应诱导的失血性休克血管反应性和钙敏感性保护[J].陆军军医大学学报(原第三军医大学学报),2010,32(17):1807.
 Xu Jing,Yang Guangming,Li Tao,et al.Protective effect of ischemia preconditioning on vascular reactivity and calcium sensitivity in rats after hemorrhagic shock[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(14):1807.
[4]陈垦,刘良明.缺氧诱导因子-1α对失血性休克大鼠肠系膜上动脉血管环舒张反应性的调控作用[J].陆军军医大学学报(原第三军医大学学报),2010,32(04):319.
 Chen Ken,Liu Liangming.Effect of hypoxia-inducible factor-1α on vascular relaxation reactivity following hemorrhagic shock in rats[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(14):319.
[5]贾立峰,张连阳,李勇.失血性休克复苏后CO2气腹对兔肝功能及肝血流量的影响[J].陆军军医大学学报(原第三军医大学学报),2009,31(11):1021.
 JIA Li-feng,ZHANG Lian-yang,LI Yong.Effects of CO2 pneumoperitoneum on hepatic function and hepatic blood flow after hemorrhagic shock resuscitation in rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(14):1021.
[6]李涛,刘良明,刁有芳,等.评价携氧抗休克液体的动物模型建立[J].陆军军医大学学报(原第三军医大学学报),2009,31(01):64.
 LI Tao,LIU Liang-ming,DIAO You-fang,et al.Rat model of hemorrhagic shock to evaluate antishock effect of oxygen-carrying shock resuscitation fluid[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(14):64.
[7]徐竞,蓝丹,李涛,等.线粒体KATP在吡那地尔预处理后失血性休克大鼠组织血流灌注和线粒体功能保护效应中的作用[J].陆军军医大学学报(原第三军医大学学报),2011,33(23):2441.
 Xu Jing,Lan Dan,Li Tao,et al.Role of mitochondrial KATP channel in pinacidil pretreatment-induced protective effect on blood flow and mitochondrial function of hemorrhagic shock rats[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(14):2441.
[8]胡新宇,陶军,杨天德,等.中分子量羟乙基淀粉对脊髓损伤后神经病理性疼痛的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(23):2480.
 Hu Xinyu,Tao Jun,Yang Tiande,et al.Effect of medium molecular weight hydroxyethyl starch on neuropathic pain in rats after spinal cord injury[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(14):2480.
[9]但飞君,刘良明,卢儒权,等.TRH抗高原创伤失血性休克大鼠的作用[J].陆军军医大学学报(原第三军医大学学报),1999,21(02):0.[doi:10.16016/j.1000-5404.1999.02.034 ]
[10]王丽,谢镒鞠,唐小唪,等.创伤失血性休克后腹腔高压对心肺基础监测指标的影响[J].陆军军医大学学报(原第三军医大学学报),2013,35(20):2159.
 Wang Li,Xie Yiju,Tang Xiaofeng,et al.Effect of intra-abdominal hypertension after traumatic hemorrhagic shock on porcine respiratory and circulatory parameters[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(14):2159.
[11]李涛,刘良明,刁有芳,等.几种不同液体复苏失血性休克大鼠的适宜量研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(03):199.
 LI Tao,LIU Liang-ming,DIAO You-fang,et al.On proper volume of different fluids for hemorrhagic shock resuscitation in rats[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):199.
[12]王海英,曾洪波,靳琼瑶,等.两种胶体用于治疗失血性休克犬对红细胞免疫功能影响的对比研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(17):1647.
 WANG Hai-ying,ZENG Hong-bo,JIN Qiong-yao,et al.Effect of two colloidal fluids on red blood cell immune function in dog model of hemorrhagic shock[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(14):1647.
[13]李涛,刘良明,刁有芳,等.不同液体对失血性休克大鼠复苏效果的影响[J].陆军军医大学学报(原第三军医大学学报),2009,31(06):467.
 LI Tao,LIU Liang-ming,DIAO You-fang,et al.Effects of different resuscitation fluids on hemorrhagic shock in rats[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(14):467.
[14]陈方祥,滕方,廖自福,等.非控制失血性休克大鼠输液输血的研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(11):1029.
 CHEN Fang-xiang,TENG Fang,LIAO Zi-fu,et al.Resuscitation for hemorrhagic shock rats: lactated Ringer’s solution with whole blood or red blood cells[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(14):1029.

更新日期/Last Update: 2008-07-17