[1]覃容欣,罗圣霖,周向东.苔藓蒽噻吩-1-羧酸甲酯的合成[J].第三军医大学学报,2007,29(22):2124-2127.
　QIN Rong-xin,LUO Sheng-lin,ZHOU Xiang-dong.Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate[J].J Third Mil Med Univ,2007,29(22):2124-2127.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第22期
页码:
2124-2127
栏目:
论著
出版日期:
2007-11-30

文章信息/Info

Title:
Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate
作者:
覃容欣; 罗圣霖; 周向东
第三军医大学医学检验系药学院药物化学教研室
Author(s):
QIN Rong-xin;  LUO Sheng-lin;  ZHOU Xiang-dong
Department of Medicinal Chemistry, College of Medical Laboratory, Third Military Medical University, Chongqing 400038, China
关键词:
苔藓蒽噻吩; 苔藓蒽噻吩-1-羧酸甲酯; 1; 8-二羟基-9; 10-蒽醌; 区域选择性硝化
Keywords:
bryoanthrathiophene;  methyl bryoanthrathiophene-1-carboxylate;  1; 8-dihydroxy-9; 10-anthraquinone;  regioselective nitration
分类号:
R914
文献标志码:
A
摘要:
目的  高效合成目标分子苔藓蒽噻吩-1-羧酸甲酯。  方法  以1，8-二羟基-9，10-蒽醌为原料，经过保护、硝化、巯代、环合和脱保护5步反应，合成目标分子。  结果  以45.8%的总收率合成目标分子。  结论  高效合成了苔藓蒽噻吩-1-羧酸甲酯。本方法具有合成路线短、选择性好和合成效率高等特点。
Abstract:
Objective    To study the synthesis of methyl bryoanthrathiophene-1-carboxylate with high efficiency.     Methods    Target compounds were synthesized from 1,8-dihydroxy-9,10-anthraquinone via 5 steps including protecting, nitration, methyl mercaptoacetate substitution, intramolecular Aldol reaction and deprotecting.     Results    Target molecule was synthesized in the total yield of 45.8%.     Conclusion    Our synthesis of methyl bryoanthrathiophene-1-carboxylate is characterized by short synthetic route, high selectivity and high efficiency.

相似文献/References:

[1]罗圣霖,覃容欣,周向东.血管生成抑制剂候选物——去甲苔藓蒽噻吩的设计合成[J].第三军医大学学报,2008,30(07):592.
　LUO Sheng-lin,QIN Rong-xin,ZHOU Xiang-dong.Design and synthesis of demethyl bryoanthrathiophene, a new potential angiogenesis inhibitor[J].J Third Mil Med Univ,2008,30(22):592.

更新日期/Last Update: 2008-07-01