[1]张丽龙,艾国平,粟永萍,等.异黄酮类化合物F11抗癌活性的实验研究[J].第三军医大学学报,2007,29(12):1155-1157.
 ZHANG Li-long,AI Guo-ping,SU Yong-ping,et al.On anticancer activity of isoflavone derivative F11[J].J Third Mil Med Univ,2007,29(12):1155-1157.
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异黄酮类化合物F11抗癌活性的实验研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第12期
页码:
1155-1157
栏目:
论著
出版日期:
2007-06-30

文章信息/Info

Title:
On anticancer activity of isoflavone derivative F11
作者:
张丽龙艾国平粟永萍程天民郑虎翁玲玲
第三军医大学军事预防医学院防原医学教研室,全军复合伤研究所,创伤、烧伤与复合伤国家重点实验室;四川大学华西药学院药物化学教研室
Author(s):
ZHANG Li-long AI Guo-ping SU Yong-ping CHENG Tian-min ZHENG Hu WENG Ling-ling
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038; West China School of Pharmacy, Sichuan University, Chengdu 610041, China
关键词:
异黄酮 Hela MTT裸鼠
Keywords:
isoflavone Hela MTT nude mice
分类号:
R73-361;R914.4
文献标志码:
A
摘要:
目的    研究经结构修饰后的异黄酮类化合物F11是否具较好的体外、体内抗癌活性。    方法    采用MTT法,以5,7,4′-三羟基异黄酮(genistein, GEN)作为对照,研究化合物F11对Hela细胞的抗增殖作用;采用荷瘤裸鼠模型,以GEN和环磷酰胺作为对照,研究化合物F11在体抗癌效应。    结果    MTT实验结果显示,在相同的作用浓度下,F11处理组Hela细胞形态异常改变,死细胞明显增多,细胞存活率显著低于GEN作用组(P<0.05)。荷瘤动物实验结果表明与GEN相比,F11对Hela细胞裸鼠移植瘤的生长有显著的抑制作用(P<0.01),效果与环磷酰胺相当,且未观察到毒副反应。    结论    异黄酮类化合物经过特定结构修饰,可显著增强其抗癌效应,有值得进一步研究开发的潜在价值。
Abstract:
Objective    To investigate whether structurally modified isoflavone derivatives have better antitumor activity in vivo and in vitro.     Methods    The antiproliferative activity of compound F11 against Hela strain cells was analyzed by MTT and compared with that of Genistein. The nude mouse loading Hela tumor cells was used to evaluate the in vivo antitumor activity of F11 and the results were compared with that of Genistein and Cytoxan.      Results    Compound F11 had better performance than Genistein in antitumor tests as revealed by in vitro MTT measurement and in vivo nude mice model loading Hela tumor cells.     Conclusion    Isoflavone derivatives could be modified to acquire potent cytotoxicity on tumor cells, which are of potential clinical value and worth further investigation.

参考文献/References:

张丽龙,艾国平,粟永萍,等. 异黄酮类化合物F11抗癌活性的实验研究[J]. 第三军医大学学报, 2007, 29(12):1155-1157.

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[1]张丽龙,粟永萍,刘晓宏,等.新型异黄酮及甾体类化合物体外抗癌细胞增殖活性的初步筛选[J].第三军医大学学报,2006,28(13):1393.

更新日期/Last Update: 2008-10-23