[1]范伟,杨妤欣,陈隽,等.糖尿病大鼠早期骨微结构改变及其BMP-2基因的表达[J].第三军医大学学报,2007,29(11):1053-1056.
 FAN Wei,YANG Yu-xin,CHEN Juan,et al.Bone microstructure changes and bone BMP-2 expression in rats at early period of diabetes[J].J Third Mil Med Univ,2007,29(11):1053-1056.
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糖尿病大鼠早期骨微结构改变及其BMP-2基因的表达
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第11期
页码:
1053-1056
栏目:
论著
出版日期:
2007-06-15

文章信息/Info

Title:
Bone microstructure changes and bone BMP-2 expression in rats at early period of diabetes
作者:
范伟 杨妤欣陈隽蒋电明
重庆医科大学:附属第一医院骨科,附属第二医院内分泌科;重庆大学生物工程学院
Author(s):
FAN Wei YANG Yu-xin CHEN Juan JIANG Dian-ming
Department of Bone Surgery, The First Affiliated Hospital, Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016; College of Bioengineering, Chongqing University, Chongqing 400044, China
关键词:
糖尿病骨微结构BMP-2
Keywords:
diabetes mellitus bone microstructure BMP-2 expression
分类号:
R329.26; R336; R587.102
文献标志码:
A
摘要:
目的    观察糖尿病大鼠早期的骨密度、骨微结构改变及骨组织中BMP-2基因的表达。    方法    清洁级健康成年雄性Wistar大鼠30只,按照随机数字表将其分为A组(普通饲料对照组)、B组(高脂饲料+链脲佐菌素组)和C组(普通饲料+大剂量链脲佐菌素组)。饲养12周后,分别对各组大鼠进行骨密度、光镜、扫描电镜、骨形态计量学的观察以及BMP-2基因表达等指标的检测。    结果    与A组相比,B组骨微结构无明显变化(P>0.05),但BMP-2基因表达增高(P<0.05),C组骨微结构明显改变(P<0.05),BMP-2基因表达降低,但差异无统计学意义(P>0.05)。    结论    不同的糖尿病大鼠模型早期骨微结构及BMP-2基因表达情况改变不完全一致,可能与高胰岛素血症、胰岛素抵抗有一定关系。
Abstract:
Objective    To investigate the changes of bone density, bone microstructure, bone BMP-2 expression in rats at early period of diabetes.     Methods    Thirty SPF 4-month-old male Wistar rats were randomly divided into 3 groups (n=10 in each group): A (fed with common forage as normal control group), B (fed with high-lipid forage and intraperitoneally injected with STZ to establish type 2 diabetes with insulin resistance), C (fed with common forage and intraperitoneally injected with STZ to establish type 2 diabetes with insulin secretion defaulting). The bone histomorphology, bone histomorphometry, bone BMP-2 expression were investigated 12 weeks later.     Results    As compared with group A, bone microstructure was of no obvious changes and bone BMP-2 expression was higher in group B (P<0.05), and obvious bone breakage was observed in group C (P<0.05).     Conclusion    The changes of bone microstructure and bone BMP-2 expression at the early period of diabetes are not consistent absolutely in individual rat model of diabetes. It maybe relate to hyperinsulinism and insulin resistance.

参考文献/References:

范伟, 杨妤欣, 陈隽, 等. 糖尿病大鼠早期骨微结构改变及其BMP-2基因的表达[J]. 第三军医大学学报, 2007, 29(11):1053-1056.

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更新日期/Last Update: 2008-10-23