[1]陈秀明,艾国平,粟永萍,等.新型异黄酮类化合物对去势大鼠股骨生物力学性能影响的实验研究[J].第三军医大学学报,2007,29(11):1039-1041.
 CHEN Xiu-ming,AI Guo-ping,SU Yong-ping,et al.Effect of a novel isoflavone compound on femoral biomechanics of ovarectomied rats[J].J Third Mil Med Univ,2007,29(11):1039-1041.
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新型异黄酮类化合物对去势大鼠股骨生物力学性能影响的实验研究
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第11期
页码:
1039-1041
栏目:
论著
出版日期:
2007-06-15

文章信息/Info

Title:
Effect of a novel isoflavone compound on femoral biomechanics of ovarectomied rats
作者:
陈秀明艾国平粟永萍张丽龙陈诚常青陈卫军
第三军医大学:西南医院妇产科,军事预防医学院防原医学教研室,全军复合伤研究所,烧伤、创伤与复合伤国家重点实验室,基础医学部人体解剖学教研室,重庆市生物力学实验室
Author(s):
CHEN Xiu-mingAI Guo-pingSU Yong-pingZHANG Li-longCHEN ChengCHANG QingCHEN Wei-jun
Department of Gynaecology and Obstetrics, Southwest Hospital; State Key Laboratory of  Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Department of Anatomy, College of Medicine,  Third Military Medical University,  Chongqing 400038, China
关键词:
F11骨质疏松生物力学骨组织形态学
Keywords:
F11 osteoporosis biomechanics bone tissue morphology
分类号:
R322.71; R336; R977.12
文献标志码:
A
摘要:
目的    探讨改构后的异黄酮类化合物F11对去势大鼠股骨生物力学性能的影响。    方法    采用去卵巢大鼠模型,分为造模组、假手术组(sham组)及不同浓度的F11组(低、中、高F11组),腹腔注射每日1次连续用药10周后活杀大鼠,取股骨测量生物力学参数和进行股骨组织形态学观察,评价F11对去势大鼠股骨生物力学性能的影响。    结果    F11组大鼠股骨的最大载荷、挠度载荷、弹性模量等指标与造模组比较有显著提高(P<0.05);骨组织形态学结果显示去势大鼠股骨骺端骨质排列疏松、骨小梁排列紊乱,稀疏;高、中、低剂量F11组大鼠股骨骺端骨质排列整齐,骨小梁排列整齐。    结论    经改构后的新型异黄酮类化合物F11可能提高去势大鼠股骨抵抗外力冲击的能力和骨韧性,降低骨折发生的危险性。
Abstract:
Objective    To investigate the influence of a novel isoflavone compound, F11, on femoral biomechanics of ovarectomied rats.     Methods    The ovarectomied rat models were randomly assigned to five groups: control, sham operation, and three experimental groups in which F11 of  different concentrations were intraperitoneally injected once a day for ten weeks. Ten weeks later, all rats were killed and the left femurs harvested to determine the bony biomechanic and histology.     Results    The maximal load, flexibility load, and elastic modulus in F11 groups were remarkably enhanced as compared with sham operation group and control group. Osteoporosis at the epiphysis, trabecular alignment derangement and sparseness were seen in ovarectomied rats, but the changes were substantially mild in F11 groups.     Conclusion    F11 can enhance the ability of the femur to resist the impact of external force in ovarectomied rats, improve bony tenacity, and as a result will reduce the dangers of bone fracture.

参考文献/References:

陈秀明, 艾国平, 粟永萍, 等. 新型异黄酮类化合物对去势大鼠股骨生物力学性能影响的实验研究[J]. 第三军医大学学报, 2007, 29(11):1039-1041.

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更新日期/Last Update: 2008-10-23