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乳腺癌雌激素受体β表达与临床病理及预后标志物的关系
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第11期
页码:
1090-1092
栏目:
论著
出版日期:
2007-06-15

文章信息/Info

Title:
Association of ERβ expression with the clinical pathologic indexes and prognostic biomarkers of breast cancer
作者:
周艳张毅梁燕姜军
第三军医大学西南医院乳腺疾病中心
Author(s):
ZHOU Yan ZHANG Yi LIANG Yan JIANG Jun
Breast Disease Centre, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
关键词:
乳腺肿瘤雌激素受体预后
Keywords:
breast neoplasm estrogen receptor prognosis
分类号:
R392.1; R730.23; R737.9
文献标志码:
A
摘要:
目的    探讨雌激素受体亚型ERβ在乳腺组织中的表达及其与ERα、PR、其他生物学预后标志物以及和临床病理参数的关系。    方法    采用组织芯片和免疫组化技术,比较109 例原发性乳腺癌患者中ERβ表达与ERα、PR、其他生物学预后标志物以及和临床病理参数的关系。    结果    ERβ蛋白在良性上皮细胞和间质细胞中均有表达,不同乳腺癌组织类型中59%ERβ表达阳性,其中45 %病例ERβ和ERα同时表达。统计学分析结果显示,ERβ阳性表达组中,HER-2/neu和p53蛋白表达率显著高于ERβ阴性组,而ERβ表达与否同各临床指标间无显著性差异。    结论    ERβ可能是乳腺癌重要的预后指标及治疗靶点。
Abstract:
Objective    To study the association of ERβ expression with the expression of hormonal receptor and prognostic biomarkers.     Methods    The expressions of ERβ, ERα, PR, Ki-67, HER-2/neu and p53 were detected in tissue samples from 109 breast cancer patients by immunohistochemistry on tissue microarray slides. The histologic grade,  tumor size and lymph node metastasis status of 109 cases of breast cancer were recorded and served as comparison indexes.     Results    ERβ was expressed in benign epithelium and stroma cells, and breast cancer cells in 59% breast cancer tissues of different histologic types. ERβ was coexpressed with ERα in 45% breast cancer tissues. ERβ expression was found a statistically significant association with HER-2/neu (P<0.05) and p53 (P<0.05). No statistically significant association was seen between ERβ expression and histologic grade, tumor size and lymph node metastasis.     Conclusion    ERβ may be an important prognostic marker and therapeutic target in breast cancer.

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更新日期/Last Update: 2008-10-23