[1]张献菊.丙氨酰谷氨酰胺双肽全肠外营养在胃肠道肿瘤患者术后的应用[J].陆军军医大学学报(原第三军医大学学报),2007,29(11):1120-1122.
 ZHANG Xian-ju.Application of total parenteral nutrition with alanyl-glutamine dipeptide in postoperative patients of gastrointestinal neoplasms[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(11):1120-1122.
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丙氨酰谷氨酰胺双肽全肠外营养在胃肠道肿瘤患者术后的应用
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第11期
页码:
1120-1122
栏目:
论著
出版日期:
2007-06-15

文章信息/Info

Title:
Application of total parenteral nutrition with alanyl-glutamine dipeptide in postoperative patients of gastrointestinal neoplasms
作者:
张献菊
重庆医科大学附属儿童医院药剂科
Author(s):
ZHANG Xian-ju
Department of Pharmacy, The Children’s Hospital,  Chongqing Medical University, Chongqing 400014, China
关键词:
丙氨酰谷氨酰胺全肠外营养胃肠道肿瘤患者
Keywords:
alanyl-glutamine TPN gastrointestinal neoplasms
分类号:
R459.3; R735; R977.4
文献标志码:
A
摘要:
目的    探讨丙氨酰谷氨酰胺(Gla-Gln)双肽全肠外营养(total parenteral nutrition, TPN)在胃肠道肿瘤患者术后的应用。    方法    64 例胃肠道肿瘤患者术后分为常规TPN 组(对照组) 32 例和TPN + Gla-Gln 组(实验组) 32 例,所有患者术后第1~7 天等热量(96.0 kJ·kg-1·d-1)、等氮(0.25 g·kg-1·d-1)的肠外营养治疗,实验组另外添加0.5 g·kg-1·d-1的Gla-Gln双肽。观察血清白蛋白、血清前蛋白、氮平衡变化,并检测手术前后外周血IgG、IgM、IgA、C3 、C4 的变化。    结果    ①两组患者血清白蛋白、前白蛋白在术后第1天均有下降,与术前相比差异非常显著(P<0.01),术后第8天时两组均有回升,但对照组回升较慢,两组比较有显著性差异(P<0.05)。 ②两组患者术后第4天IgG、IgA、IgM值均低于术前,与术前相比两组均有非常显著的差异(P<0.01),实验组术后第8天IgG、IgA、IgM明显回升并高于术前,与对照组比较有显著性差异(P<0.05)。实验组术后第8天C3、C4值与对照组比较有显著性差异(P<0.05)。③实验组术后第8天氮平衡明显优于对照组(P<0.01)。    结论    丙氨酰谷氨酰胺双肽全肠外营养在胃肠道肿瘤手术患者中使用安全,有助于改善患者术后的营养状况,提高患者的免疫功能。
Abstract:
Objective    To investigate the application of total parenteral nutrition with alanyl-glutamine dipeptide in postoperative patients of gastrointestinal neoplasms.     Methods    Sixty-four postoperative patients of gastrointestinal neoplasms were randomly divided into study group and control group. The patients in the two groups all received isocaloric (96.0 kJ·kg-1·d-1) and isonitrogen (0.25 g·kg-1·d-1) parenteral nutrition from postoperative day 1 to day 7, and the study group received additional alanyl-glutamine. The serum levels of albumin, pre-albumin, IgG, IgA, IgM, C3, C4 were measured before operation and on postoperative day 1 and 8. Nitrogen balance was calculated on postoperative day 1, 4 and 8.     Results    Compared with preoperation, the serum levels of albumin and pre-albumin were both significantly decreased in two groups (P<0.01). Compared with those of preoperation, IgG, IgM IgA levels were decreased significantly on preoperative day 4 in two groups (P<0.01), and increased in the study group on postoperative day 8 (P<0.05). C3 and C4 levels in the study group were increased more than those in the control group (P<0.05) on postoperative day 8. Nitrogen balance in the study group was better than those in the control group (P<0.05) on postoperative day 8.      Conclusion    Alanyl-glutamine dipeptide is beneficial to postoperative patients of gastrointestinal neoplasms, and can improve their nutritional status, enhance their immune function.

相似文献/References:

[1]张军,王严庆,王致天,等.胃肠道肿瘤患者围手术期不同营养支持方法的研究[J].陆军军医大学学报(原第三军医大学学报),2006,28(08):844.

更新日期/Last Update: 2008-10-23