[1]石全红,廖正步,支兴刚,等.凋亡抑制基因survivin在脑膜瘤的表达及其与bcl-2、bax的相关性[J].第三军医大学学报,2007,29(03):253-255.
 SHI Quan-hong,LIAO Zheng-bu,ZHI Xing-gang,et al.Expression of survivin and its relationship with bcl-2 and bax expressions in meningiomas[J].J Third Mil Med Univ,2007,29(03):253-255.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
29卷
期数:
2007年第03期
页码:
253-255
栏目:
论著
出版日期:
2007-02-15

文章信息/Info

Title:
Expression of survivin and its relationship with bcl-2 and bax expressions in meningiomas
作者:
石全红廖正步支兴刚唐雄伟
重庆医科大学附属第一医院神经外科;重庆合川市人民医院外三科
Author(s):
SHI Quan-hong LIAO Zheng-bu ZHI Xing-gang TANG Xiong-wei
Department of Neurosurgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, Third Department of Surgery, People’s Hospital of Hechuan, Chongqing 401520, China
关键词:
脑膜瘤survivin细胞凋亡bcl-2bax
Keywords:
meningiomas survivin apoptosis bcl-2 bax
分类号:
R394.3;R730.23;R739.41
文献标志码:
A
摘要:
目的     探讨凋亡抑制基因survivin在脑膜瘤的表达,及其与bcl-2、bax的相关性。     方法     应用免疫组织化学S-P法,检测60例脑膜瘤瘤组织中survivin、bcl-2、bax蛋白的表达,并结合临床病理参数进行综合分析。     结果     脑膜瘤Ⅰ级中survivin蛋白表达率为32.0%,Ⅱ级为60.0%,Ⅲ级为86.7%,各级之间survivin蛋白表达率的差异有统计学意义(P<0.05),并且survivin蛋白的表达与肿瘤的侵袭行为、瘤周水肿显著相关(P<0.05);survivin表达与bcl-2表达呈正相关(P<0.05),与bax表达呈负相关(P<0.05)。     结论     survivin在脑膜瘤的表达与其恶性程度有关,随恶性程度升高而增高,因此survivin可能通过抑制脑膜瘤细胞凋亡,对脑膜瘤的发生、发展起一定作用;survivin与bcl-2、bax在脑膜瘤的发生、发展中分别起协同和拮抗作用。
Abstract:
Objective     To study the expression of apoptosis inhibited gene survivin and its relationship with the expressions of bcl-2 and bax in meningiomas.      Methods     Expressions of survivin, bcl-2 and bax proteins were detected by immunohistochemical method (S-P) in 60 samples of meningiomas respectively. The correlation between them was analyzed in combination with clinical pathological data.      Results     The expression rate of survivin protein was 32.0% in gradeⅠ, 60.0%, in grade Ⅱ, and 86.7% in gradeⅢ, with significant differences among the 3 groups (P<0.05). The positive ratio was closely correlated with aggressive behavior (P<0.05) and peritumoral edema (P<0.05) respectively. Expressions of bcl-2 and bax proteins was positively and negatively correlated with the expression of survivin protein respectively.      Conclusion     The expression of survivin in meningiomas is closely correlated with its malignancy. Survivin may play an important role in the pathogenesis of malignant meningiomas. Bcl-2 may play a synergic role while bax an antagonistic role to survivin gene in the formation and progression of meningiomas.

参考文献/References:

石全红, 廖正步, 支兴刚, 等. 凋亡抑制基因survivin在脑膜瘤的表达及其与bcl-2、bax的相关性[J]. 第三军医大学学报,2007,29(3):253-255.

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更新日期/Last Update: 2008-11-13