|Table of Contents|

Predictive value of HR-HPV and SCC-Ag assessment during follow-up for recurrence of postoperative cervical cancer

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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

Issue:
2018年第11期
Page:
1033-1037
Research Field:
临床医学
Publishing date:

Info

Title:

Predictive value of HR-HPV and SCC-Ag assessment during follow-up for recurrence of postoperative cervical cancer

Author(s):

LIU Yu LI Li CHEN Jiankun GUO Jianxin HAN Jian ZHENG Xiuhui

Department of Obstetrics and Gynecology, Institute of Surgery Research, Third Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China

Keywords:

cervical cancer high-risk human papilloma virus squamous cell carcinoma antigen recurrence

PACS:
R373.9; R730.43; R737.33
DOI:
-
Abstract:

Objective    To explore the value of predicting recurrence of postoperative cervical cancer by monitoring high-risk human papilloma virus (HR-HPV) and squamous cell carcinoma antigen (SCC-Ag) during followingup. Methods    A total of 406 women who underwent radical or subtotal hysterectomy, or cervical conization or radical trachelectomy due to cervical cancer in our department from January 2012 to December 2016 were prospectively enrolled in this study. During the routine follow-up, HR-HPV and SCC-Ag assessment was performed. The relationship of recurrence with HR-HPV and SCC-Ag was analyzed, and the differences of single detection and joint detection were compared in the prediction of recurrence. Results    Compared those unrecurrent patients, those recurrent had higher HR-HPV persistent positive rate (P<0.001), and higher positive rate of SCC-Ag (P<0.001). The patients with pelvic recurrence had a higher persistent positive rate of HR-HPV than those with distant metastasis (P<0.05), but no such difference was seen in the positive rate of SCC-Ag between those with recurrence and with distant metastasis (P>0.05). In the prediction of recurrence of cervical cancer, single detection of HR-HPV had higher sensitivity (57.9%), and single detection of SCCAg showed higher specificity (95.1%)(both P<0.05). Whereas, joint detection of HR-HPV and SCC-Ag obtained higher sensitivity (76.3%) than single detection (P<0.05). Conclusion    Assessment of HR-HPV and SCC-Ag during following-up can warn the recurrence of cervical cancer in a certain extent, and joint detection can improve the sensitivity of prediction.

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Last Update: 2018-06-14