|Table of Contents|

Correlation between salt taste threshold and severity of coronary heart disease



Research Field:
Publishing date:



Correlation between salt taste threshold and severity of coronary heart disease


MA Wenlian TAO Guihui YANG Xiaoli SUN Hongxia ZHANG Xiaoqun LIU Lei

Department of Cardiology, Institute of Surgery Research, Third Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042; Department of Cardiology, Chongqing Fifth People’s Hospital, Chongqing, 400062; Department of Nursing, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China


coronary heart disease salt taste threshold Gensini score

R151.1; R181.23; R541.4

Objective    To investigate the correlation between salt taste threshold and severity of coronary heart disease. Methods    A cross-section study was performed on 198 patients with coronary heart disease diagnosed by coronary angiography admitted in the Third Affiliated Hospital of Army Medical University from October 2017 to January 2018. Another sex-and age-matched 193 patients without coronary artery stenosis by coronary angiography served as control group. According to the number of coronary lesion, the patients of the coronary heart disease group was further divided into single branch lesion, double branch lesion and triple branch lesion subgroups. And based on Gensini score, the severity of coronary lesion was evaluated. The patients’ salt taste threshold was determined by using NaCl solution. The differences of salt taste threshold among the above groups were compared, and the correlation between salt taste threshold and severity of coronary heart disease was analyzed. Results    The salt taste threshold was significantly higher in the coronary heart disease group than the control group [(0.75±0.21)% vs (0.59±0.18)%, P<0.05]. With the increase of diseased arteries, the threshold was elevated. After adjustment of traditional risk factors of coronary heart disease using logistic regression model, elevated salt taste threshold was found to increase the prevalence of coronary heart disease (OR=3.012, P<0.05). Salt taste threshold was positively correlated with the severity of coronary artery disease (Gensini score, r=0.623, P<0.05). Conclusion     Elevated salt taste threshold is a risk factor for coronary heart disease, and it is also positively correlated with the severity of the disease.


[1]FAZELI MOGHADAM E,TADEVOSYAN A,FALLAHI E,et al. Nutritional factors and metabolic variables in relation to the risk of coronary heart disease: A case control study in Armenian adults[J]. Diabetes Metab Syndr,2017,11(1):7-11. DOI:10.1016/j.dsx.2016.06.013.
[2]GHISI G L M,CHAVES G S D S,BRITTO R R,et al. Health literacy and coronary artery disease: A systematic review [J]. Patient Educ Couns,2017,101(2018):177-184. DOI:10.1016/j.pec.2017.09.002.
[3]YU H,LI D,CHU X,et al. Coronary heart disease: incidence,risk factors and interventions in Jiaozhou of Shandong province [J]. Chin Med J(Engl), 2014, 127(12):2275-2278.
[4]VIJAYVERGIYA R,KAPOOR D,AGGARWAL A,et al. Analysis of traditional and emerging risk factors in premenopausal women with coronary artery disease:A pilotscale study from North India [J]. Mol Cell Biochem, 2017, 432(1/2):67-78. DOI:10.1007/s1101001729989.
[5]CHERAGHI M,SHAHSAVARI G,MALEKI A, et al. Paraoxonase 1 activity,lipid profile,and atherogenic indexes status in coronary heart disease[J]. Rep Biochem Mol Biol,2017,6(1):1-7.
[6]GHADERI F,ESHRAGHI A,SHAMLOO A S,et al. Assosiation of epicardial and pericardial fat thickness with coronary artery disease[J]. Electron Physician,2016,8(9):2982-2989.
[7]KIM C Y,YE M K,LEE Y S. The salttaste threshold in untreated hypertensive patients[J]. Clin Hypertens, 2017, 23:22. DOI:10.1186/s4088501700798.
[8]DEVERE R. Disorders of taste and smell[J]. Continuum (Minneap Minn),2017,23(2):421-446. DOI: 10.1212/CON.0000000000000463.
[9]COHEN J,WAKEFIELD C E,LAING D G. Smell and taste disorders resulting from cancer and chemotherapy[J]. Curr Pharm Des,2016,22(15):2253-2263.
[10]BASSON M D,BARTOSHUK L M,DICHELLO S Z,et al. Association between 6npropylthiouracil(PROP) bitterness and colonic neoplasms [J]. Dig Dis Sci,2005,50(3): 483-489.
[11]KIM T H,KIM Y H,BAE N Y,et al. Salty taste thresholds and preference in patients with chronic kidney disease according to disease stage:A crosssectional study[J]. Nutr Diet,2018,75(1):59-64. DOI: 10.1111/17470080.
[12]LIU Z,TANG Z,ZHANG K Q,et al. Salty food preference is associated with osteoporosis among Chinese men[J]. Asia Pac J Clin Nutr,2016,25(4):871-878. DOI:10.6133/apjcn.102015.06.
[13]ROURA E, FOSTER S, WINKLEBACH A, et al. Taste and hypertension in humans:targeting cardiovascular disease[J]. Curr Pharm Des,2016,22(15):2290-2305.
[14]MIZUTA E. Impact of taste sensitivity on lifestylerelated diseases[J]. Yakugaku Zasshi,2015,135(6):789-792. DOI:10.1248/yakushi.14002505.
[15]UOTA M,OGAWA T,IKEBE K,et al. Factors related to taste sensitivity in elderly: crosssectional findings from SONIC study [J]. J Oral Rehabil, 2016, 43(12):943-952. DOI: 10.1111/joor.12442.
[16]ZUMKLEY H,VETTER H,MANDELKOW T,et al. Taste sensitivity for sodium chloride in hypotensive, normotensive and hypertensive subjects[J]. Nephron,1987,47(1):132-134.
[17]LI Q,JIN R,YU H,et al. Enhancement of Neural Salty Preference in Obesity[J]. Cell Physiol Biochem,2017,43(5):1987-2000. DOI:10.1159/000484122.
[18]HUANG Z,HUANF S,CONG H,et al. Smell and taste dysfunction is associated with higher serum total cholesterol concentrations in Chinese adults[J]. J Nutr,2017,147(8):1546-1551. DOI:10.3945/jn.117.250480.
[19]DUFFY V B. Associations between oral sensation,dietary behaviors and risk of cardiovascular disease(CVD)[J]. Appetite,2004,43(1):5-9.


Last Update: 2018-06-14