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Risk factors for hemorrhage in hospitalized premature infants: analysis of 615 cases



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Risk factors for hemorrhage in hospitalized premature infants: analysis of 615 cases


CHEN Yuanli XU Ying

Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Chongqing, 400014; Department of Anesthesiology, Chongqing Emergency Medical Center, Chongqing, 400014, China


premature infants hemorrhage risk factors


Objective     To analyze the related risk factors for premature infant hemorrhage. Methods      A retrospective study was carried out on 615 hospitalized premature newborns in the Children’s Hospital from January 2014 to January 2016. Their clinical data (including basic information, perinatal factors, and bleeding) and laboratory results (coagulation indexes, platelet count, and white blood cell count) were collected. The infants were divided into 2 groups according to having or having not hemorrhage. Univariate analysis and  logistic regression analysis were used to identify independent variables of considerable significance. Results     Univariate analysis revealed that significant differences were found in prothrombin time (PT) and fibrinogen (FIB) between the 2 groups (P<0.05, P<0.01), but not in the gestational age, asphyxia history, white blood cell count, and platelet count. While multivariate logistic regression analysis showed that there were significant differences in gestational age, asphyxia resuscitation history, platelet count, white blood cell count and FIB value between the 2 groups (P<005). Longer gestational age, and higher platelet count and FIB value were protective factors, while asphyxia resuscitation history and higher white blood cell count were risk factors. Conclusion      Short gestational age, history of asphyxia resuscitation, high white blood cell count, and low platelet count and FIB value are risk factors for premature infants hemorrhage.


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Last Update: 2017-08-23