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Epidemiological investigation of cases with complained AIDS-related complex (HIV negative)(PDF)


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Epidemiological investigation of cases with complained AIDS-related complex (HIV negative)
Liu Yaqiong Lin Hui Yu Lei Wang Qingqing Wang Taiwu Ma Xiangyu Lin Hua Wu Guohui Zhang Lu Zhou Xiangdong Xiong Wei Huang Junfu Huang Guorong Wu Long Xiang Ying Xiong Hongyan
Department of Epidemiology, College of Military Preventive Medicine, Department of Respiratory Diseases, Department of Clinical Laboratory, Southwest Hospital, Third Military Medical University, Chongqing, 400038; Chongqing Center for Disease Control and Prevention, Chongqing, 400042, China
HIV negative AIDS-related complex nontuberculosis mycobacteria tuberculin skin test (PPD test) CD4+ T lymphocyte cystic fibrosis
Objective        To investigate  the possible causes of AIDS-related complex (HIV negative) in community population.       Methods        Qualitative systematic analysis was used to screen the cases with AIDS-related complex (HIV negative) that had been reported. The possible clustering types of the clinical features of AIDS-related complex were explored based on a cross-section study that had been conducted to observe the personality and clinical features of the cases with AIDS-related complex.       Results        The qualitative systematic analysis suggested that the idiopathic CD4+ T lymphocytopenia (ICL) and infection of nontuberculosis mycobacteria (NTM) had similar characteristics with AIDS-related complex (HIV negative). Through network investigation of 174 cases and field observation of 52 cases, the data showed that the AIDS-related complex population came from different areas of China, and was dominated by young and middle-aged male patients. The complained symptoms involved respiratory tract, gastrointestinal tract, skin, muscle, skeleton and nervous system. The clinical course could be divided into an acute period and a stable period. The special symptoms are swollen lymph nodes, snapping joint, osteodynia, muscle throbbing pain, skin nodules (rash), greasy tongue coating and dry skin. The CD4+ T lymphocytes <500/μL (32.69%), the abnormal ratio of CD4/CD8 (30.77%), the positive antibody of IFN-γ (36.69%) and positive PPD (++ to +++, 75.00%) were detected in the 52 cases, and high risk sexual behavior was a suspected exposure factor.       Conclusion        The AIDS-related complex (HIV negative) in population can not be completely explained by mental disorder. The clinical features have obvious consistency and regularity, and need further study to verify.




Last Update: 2013-03-05